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How to get fromSaint Joseph to Louisvilleby bus (Greyhound), bus, train, car, plane, or bus (Greyhound, Amtrak)

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There are 10 ways to get from Saint Joseph to Louisville by bus (Greyhound), bus, train, car, plane, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St. Joseph to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville, IN to Louisville, KYbus bus
    13h 40m
    $120–213

  2. Drive 559.1 mi

    cheapest
    1. Drive from Saint Joseph to Louisvillecar car 559.1 mi
    9h 22m
    $102–148

  3. Bus, train via Chicago

    1. Take the bus from St. Joseph to Kansas Citybus bus
    2. Take the train from Kansas City to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    19h 5m
    $246–498

  4. Bus, fly to Louisville International Airport

    1. Take the bus from St. Joseph to Kansas Citybus bus
    2. Fly from Kansas City (MCI) to Louisville International Airport (SDF)plane plane MCI - SDF
    8h 13m
    $165–786

  5. Bus via Indianapolis

    1. Take the bus from St. Joseph to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    14h 15m
    $116–228

  6. Bus, train

    1. Take the bus from St. Joseph to Kansas Citybus bus
    2. Take the train from Kansas City to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville, IN to Louisville, KYbus bus
    16h
    $175–328

  7. Bus, fly to Blue Grass Airport, drive

    1. Take the bus from St. Joseph to Kansas Citybus bus
    2. Fly from Kansas City (MCI) to Blue Grass Airport (LEX)plane plane MCI - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    9h 5m
    $257–1,252

  8. Bus, fly to Nashville

    1. Take the bus from St. Joseph to Kansas Citybus bus
    2. Fly from Kansas City (MCI) to Nashville (BNA)plane plane MCI - BNA
    3. Take the bus from Nashville Bus Station to Louisville Bus Stationbus bus
    9h 29m
    $453–1,190

  9. Bus, fly to Indianapolis

    1. Take the bus from St. Joseph to Kansas Citybus bus
    2. Fly from Kansas City (MCI) to Indianapolis (IND)plane plane MCI - IND
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    9h 16m
    $706–1,096

  10. Bus, fly to Covington

    1. Take the bus from St. Joseph to Kansas Citybus bus
    2. Fly from Kansas City (MCI) to Covington (CVG)plane plane MCI - CVG
    3. Take the bus from Cincinnati to Louisvillebus bus
    11h 5m
    $185–880

Kansas City (MCI) to Louisville International Airport (SDF) flights

Calendar104Weekly Planes
Duration4h 32mAverage Duration
Ticket$141Cheapest Price
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Questions & Answers

Map of how to get from Saint Joseph to Louisville.ExpandLaunch map view
  • Distance: 584.6 mi
  • Duration: 13h 40m

What companies run services between Saint Joseph, MO, USA and Louisville, KY, USA?

You can take a bus from St. Joseph to Louisville, KY via Kansas City Bus Station, St Louis Bus Station, and Evansville, IN in around 13h 40m.

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Train operators
Bus operators

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