Rome2Rio

How to get fromSaint Marys to Chicagoby bus, plane, train, bus (Greyhound, Flixbus), car, or bus (Flixbus)

Find Transport to Chicago

See all options

There are 9 ways to get from Saint Marys to Chicago by bus, plane, train, bus (Greyhound, Flixbus), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, bus to Penn State University Park Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the bus from St. Marys to DuBoisbus bus
    2. Take the bus from DuBois to State Collegebus bus
    3. Fly from Penn State University Park Airport (SCE) to Chicago O'Hare International Airport (ORD)plane plane SCE - ORD
    7h 4m
    $86–361

  2. Bus, train

    1. Take the bus from St Marys to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    14h 36m
    $183–440

  3. Bus

    1. Take the bus from St Marys to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus bus Greyhound US0164
    14h 55m
    $103–260

  4. Drive 525.6 mi

    1. Drive from Saint Marys to Chicagocar car 525.6 mi
    9h 1m
    $96–139

  5. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the bus from St Marys to Buffalo, Nybus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    8h 3m
    $194–492

  6. Bus to Pittsburgh International Airport, fly to Chicago Midway International Airport

    1. Take the bus from St Marys to Pittsburgh, Pabus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane plane PIT - MDW
    8h 27m
    $95–485

  7. Bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from St Marys to Pittsburgh, Pabus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane plane PIT - ORD
    8h 54m
    $415–1,325

  8. Bus, train to Johnstown-Cambria County Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from St Marys to Pittsburgh, Pabus bus
    2. Take the train from Pittsburgh Amtrak Station to Johnstown Amtrak Stationtrain train
    3. Fly from Johnstown-Cambria County Airport (JST) to Chicago O'Hare International Airport (ORD)plane plane JST - ORD
    10h 18m
    $118–473

  9. Bus via Chicago

    1. Take the bus from St Marys to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus FlixBus N2640
    16h 12m
    $120–265

Saint Marys to Chicago by bus and train

Calendar7Weekly Services
Duration14h 36mAverage Duration
Ticket$183Cheapest Price
See schedules

Questions & Answers

Map of how to get from Saint Marys to Chicago.ExpandLaunch map view
  • Distance: 639.8 mi
  • Duration: 7h 4m

What companies run services between Saint Marys, PA, USA and Chicago, IL, USA?

You can take a bus from St Marys to Chicago Bus Station via Pittsburgh Intermodal Station in around 14h 55m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers