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How to get fromSaint Paul to Des Moinesby bus (Greyhound), car, or plane

Find Transport to Des Moines

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There are 3 ways to get from Saint Paul to Des Moines by bus (Greyhound), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Saint Paul Union Depot to Des Moinesbus bus Greyhound US0156
    4h 30m
    $60–90
  2. Drive  244.2 mi

    cheapest
    1. Drive from Saint Paul to Des Moinescar car 244.2 mi
    4h
    $45–65
  3. Fly

    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Des Moines (DSM)plane plane MSP - DSM
    2h 53m
    $75–406

Saint Paul to Des Moines by bus

Calendar11Weekly Buses
Duration4h 30mAverage Duration
Ticket$60Cheapest Price
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Comparing Your Travel Options

What companies run services between Saint Paul, MN, USA and Des Moines, IA, USA?

Greyhound USA operates a bus from Saint Paul Union Depot to Des Moines once daily. Tickets cost $40–65 and the journey takes 4h 30m. Jefferson Lines also services this route 4 times a week. Alternatively, Delta flies from Minneapolis–Saint Paul International Airport (MSP) to Des Moines (DSM) 4 times a day.

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