There are 3 ways to get from Saint Paul to Des Moines by bus (Greyhound), car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Saint Paul to Des Moines by bus
Comparing Your Travel Options
The cheapest way to get from Saint Paul to Des Moines is to drive which costs $40 - $65 and takes 4h.
The fastest way to get from Saint Paul to Des Moines is to fly which takes 2h 53m and costs $75 - $410.
Yes, there is a direct bus departing from Saint Paul Union Depot and arriving at Des Moines. Services depart once daily, and operate every day. The journey takes approximately 4h 30m.
The distance between Saint Paul and Des Moines is 247 miles. The road distance is 245.6 miles.
The best way to get from Saint Paul to Des Moines without a car is to bus which takes 4h 30m and costs $60 - $90.
The bus from Saint Paul Union Depot to Des Moines takes 4h 30m including transfers and departs once daily.
Saint Paul to Des Moines bus services, operated by Greyhound USA, depart from Saint Paul Union Depot station.
The best way to get from Saint Paul to Des Moines is to bus which takes 4h 30m and costs $60 - $90. Alternatively, you can fly, which costs $75 - $410 and takes 2h 53m.
Saint Paul to Des Moines bus services, operated by Greyhound USA, arrive at Des Moines station.
Yes, the driving distance between Saint Paul to Des Moines is 246 miles. It takes approximately 4h to drive from Saint Paul to Des Moines.
What companies run services between Saint Paul, MN, USA and Des Moines, IA, USA?
Greyhound USA operates a bus from Saint Paul Union Depot to Des Moines once daily. Tickets cost $40–65 and the journey takes 4h 30m. Jefferson Lines also services this route 4 times a week. Alternatively, Delta flies from Minneapolis–Saint Paul International Airport (MSP) to Des Moines (DSM) 4 times a day.
- Website
- delta.com
Flights from Minneapolis–Saint Paul International Airport to Des Moines
- Ave. Duration
- 1h 16m
- When
- Every day
- Estimated price
- $55–380
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Saint Paul Union Depot to Des Moines
- Ave. Duration
- 4h 30m
- Frequency
- Once daily
- Estimated price
- $40–65
- Website
- Greyhound
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Saint Paul Union Depot to Des Moines
- Ave. Duration
- 4h 55m
- Frequency
- 4 times a week
- Estimated price
- $60–90
- Book at
- Jefferson Lines
- Adult
- $60–90
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Booking & Getting There
Book your Saint Paul to Des Moines bus tickets online with Omio and FlixBus.
There are 256+ hotels available in Des Moines.





