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How to get fromSaint Paul to Knoxvilleby plane, bus (Greyhound, Flixbus), train, bus, or car

Find Transport to Knoxville

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There are 8 ways to get from Saint Paul to Knoxville by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS)plane plane MSP - TYS
    3h 59m
    $227–922

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Asheville Regional Airport (AVL)plane plane MSP - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    5h 53m
    $124–528

  3. Bus

    1. Take the bus from Saint Paul Union Depot to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 36m
    $387–625

  4. Train, bus

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h 17m
    $626–1,173

  5. Drive 924.1 mi

    1. Drive from Saint Paul to Knoxvillecar car 924.1 mi
    15h 38m
    $169–244

  6. Fly to Nashville, drive

    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Nashville (BNA)plane plane MSP - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 11m
    $432–1,002

  7. Train, bus via Ossining

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    42h 54m
    $581–1,100

  8. Bus, train

    1. Take the bus from Minneapolis to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    47h 23m
    $581–1,065

Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS) flights

Calendar69Weekly Planes
Duration4h 19mAverage Duration
Ticket$169Cheapest Price
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Questions & Answers

Map of how to get from Saint Paul to Knoxville.ExpandLaunch map view
  • Distance: 812.5 mi
  • Duration: 3h 59m

What companies run services between Saint Paul, MN, USA and Knoxville, TN, USA?

Delta, Southwest Airlines, and two other airlines fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Saint Paul Union Depot to Knoxville via Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 39h 36m.

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