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How to get fromSaint Paul to Louisvilleby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Amtrak)

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There are 6 ways to get from Saint Paul to Louisville by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport

    best
    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Louisville International Airport (SDF)plane plane MSP - SDF
    4h 32m
    $113–606

  2. Bus

    cheapest
    1. Take the bus from Saint Paul Union Depot to Chicago Bus Stationbus bus Greyhound US0150
    2. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus Greyhound US0100
    15h
    $110–212

  3. Train, bus

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    16h 16m
    $216–445

  4. Drive 692.1 mi

    1. Drive from Saint Paul to Louisvillecar car 692.1 mi
    11h 32m
    $127–183

  5. Fly to Blue Grass Airport, drive

    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Blue Grass Airport (LEX)plane plane MSP - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    4h 42m
    $185–972

  6. Bus via Madison

    1. Take the bus from Minneapolis to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus bus
    4. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus
    21h 36m
    $141–257

Saint Paul to Louisville by bus

Calendar56Weekly Buses
Duration15hAverage Duration
Ticket$110Cheapest Price
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Questions & Answers

Map of how to get from Saint Paul to Louisville.ExpandLaunch map view
  • Distance: 616.1 mi
  • Duration: 4h 32m

What companies run services between Saint Paul, MN, USA and Louisville, KY, USA?

Delta, Southwest Airlines, and United Airlines fly from Minneapolis–Saint Paul International Airport (MSP) to Louisville International Airport (SDF) every 4 hours. Alternatively, you can take a bus from Saint Paul Union Depot to Louisville Bus Station via Chicago Bus Station in around 15h.

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