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How to get fromSaint Paul to St. Louisby plane, train (Amtrak), bus (Greyhound), or car

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There are 5 ways to get from Saint Paul to St. Louis by plane, train (Amtrak), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Lambert–St. Louis International Airport (STL)plane plane MSP - STL
    3h 35m
    $385–956

  2. Drive 524.8 mi

    cheapest
    1. Drive from Saint Paul to St. Louiscar car 524.8 mi
    9h 31m
    $96–139

  3. Train (Amtrak)

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train Borealis / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    13h 18m
    $223–458

  4. Bus (Greyhound)

    1. Take the bus from Saint Paul Union Depot to Des Moinesbus bus Greyhound US0156
    2. Take the bus from Des Moines to St Louis Bus Stationbus bus Greyhound US0153S
    14h 50m
    $105–204

  5. Bus via MSP Terminal 1 Transit Station

    1. Take the bus from MSP Airport to Des Moinesbus bus Jefferson 803
    2. Take the bus from Des Moines to St Louis Bus Stationbus bus Greyhound US0153S
    16h 24m
    $132–222

Saint Paul to St. Louis by train (Amtrak)

Calendar21Weekly Trains
Duration13h 18mAverage Duration
Ticket$223Cheapest Price
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Questions & Answers

Map of how to get from Saint Paul to St. Louis.ExpandLaunch map view
  • Distance: 470.5 mi
  • Duration: 3h 35m

What companies run services between Saint Paul, MN, USA and St. Louis, MO, USA?

Delta and Southwest Airlines fly from Minneapolis–Saint Paul International Airport (MSP) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a train from St. Paul-Minneapolis to St. Louis via Chicago Union Station in around 13h 18m.

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