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How to get fromSan Antonio to Des Moinesby plane, bus (Flixbus), train, bus, car, or bus (Greyhound)

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There are 6 ways to get from San Antonio to Des Moines by plane, bus (Flixbus), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from San Antonio International Airport

    best
    1. Fly from San Antonio International Airport (SAT) to Des Moines (DSM)plane plane SAT - DSM
    5h 41m
    $188–872

  2. Drive 953.5 mi

    cheapest
    1. Drive from San Antonio to Des Moinescar car 953.5 mi
    15h 57m
    $174–252

  3. Bus via Denton

    1. Take the bus from San Antonio Bus Station to Dentonbus bus
    2. Take the bus from Denton to Kansas City Bus Stationbus bus
    3. Take the bus from Kansas City to Des Moinesbus bus
    22h 25m
    $188–313

  4. Train, bus

    1. Take the train from San Antonio Station to St. Louistrain train Texas Eagle
    2. Take the bus from St Louis Bus Station to Des Moinesbus bus Greyhound US0153S
    34h 12m
    $392–793

  5. Bus to Austin-Bergstrom International Airport, fly

    1. Take the bus from San Antonio Bus Station to Austin Eastside Bus Plazabus bus
    2. Fly from Austin-Bergstrom International Airport (AUS) to Des Moines (DSM)plane plane AUS - DSM
    5h 38m
    $191–898

  6. Bus

    1. Take the bus from San Antonio to Omahabus bus Aguascalientes-Omaha
    2. Take the bus from Omaha, NE to Des Moinesbus bus Greyhound US0123S
    24h 15m
    $260–281

San Antonio to Des Moines by bus

Calendar6Weekly Buses
Duration22h 25mAverage Duration
Ticket$188Cheapest Price
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Questions & Answers

Map of how to get from San Antonio to Des Moines.ExpandLaunch map view
  • Distance: 887.5 mi
  • Duration: 5h 41m

What companies run services between San Antonio, TX, USA and Des Moines, IA, USA?

American Airlines, United Airlines, and two other airlines fly from San Antonio International Airport (SAT) to Des Moines (DSM) hourly. Alternatively, you can take a bus from San Antonio Bus Station to Des Moines via Denton, Kansas City Bus Station, and Kansas City in around 22h 25m.

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