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How to get fromSan Antonio to Florida Keysby plane, bus (Greyhound, Flixbus), car, shuttle, or bus

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There are 8 ways to get from San Antonio to Florida Keys by plane, bus (Greyhound, Flixbus), car, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly San Antonio International Airport to Key West International Airport

    best
    1. Fly from San Antonio International Airport (SAT) to Key West International Airport (EYW)plane plane SAT - EYW
    9h 30m
    $188–585

  2. Bus

    1. Take the bus from San Antonio Bus Station to Houston Bus Stationbus bus
    2. Take the bus from Houston - Harrisburg Blvd to Miamibus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    34h 53m
    $246–359

  3. Drive 1,503 mi

    1. Drive from San Antonio to Florida Keyscar car 1,503 mi
    25h 48m
    $275–397

  4. Fly San Antonio International Airport to Miami International Airport, shuttle

    1. Fly from San Antonio International Airport (SAT) to Miami International Airport (MIA)plane plane SAT - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 48m
    $753–1,085

  5. Bus to Austin-Bergstrom International Airport, fly to Key West International Airport

    1. Take the bus from San Antonio Bus Station to Austin Eastside Bus Plazabus bus
    2. Fly from Austin-Bergstrom International Airport (AUS) to Key West International Airport (EYW)plane plane AUS - EYW
    10h 59m
    $202–672

  6. Fly San Antonio International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from San Antonio International Airport (SAT) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane SAT - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    11h 44m
    $493–1,305

  7. Bus to Austin-Bergstrom International Airport, fly to Miami International Airport, shuttle

    1. Take the bus from San Antonio Bus Station to Austin Eastside Bus Plazabus bus
    2. Fly from Austin-Bergstrom International Airport (AUS) to Miami International Airport (MIA)plane plane AUS - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    11h 36m
    $327–812

  8. Bus to Austin-Bergstrom International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take the bus from San Antonio Bus Station to Austin Eastside Bus Plazabus bus
    2. Fly from Austin-Bergstrom International Airport (AUS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane AUS - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    12h 1m
    $607–1,332

San Antonio International Airport (SAT) to Key West International Airport (EYW) flights

Calendar36Weekly Planes
Duration6h 31mAverage Duration
Ticket$111Cheapest Price
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Questions & Answers

Map of how to get from San Antonio to Florida Keys.ExpandLaunch map view
  • Distance: 1,113.2 mi
  • Duration: 9h 30m

What companies run services between San Antonio, TX, USA and Florida Keys, FL, USA?

Delta and American Airlines fly from San Antonio International Airport (SAT) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a bus from San Antonio Bus Station to Florida Keys via Houston Bus Station, Houston - Harrisburg Blvd, Miami, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 34h 53m.

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