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How to get fromSan Antonio to Opelousasby bus (Flixbus), train (Amtrak), car, plane, taxi, or bus

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There are 6 ways to get from San Antonio to Opelousas by bus (Flixbus), train (Amtrak), car, plane, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Flixbus)

    best
    1. Take the bus from San Antonio Bus Station to Lafayettebus bus FlixBus 2212
    7h 43m
    $77–123

  2. Fly to Lafayette Regional Airport, taxi

    cheapest
    1. Fly from San Antonio International Airport (SAT) to Lafayette Regional Airport (LFT)plane plane SAT - LFT
    2. Take the taxi from Lafayette Regional Airport (LFT) to Opelousastaxi taxi
    5h 16m
    $72–394

  3. Train (Amtrak)

    1. Take the train from San Antonio Station to Lafayette Amtrak Stationtrain train Sunset Limited
    11h 11m
    $149–295

  4. Drive 415.3 mi

    1. Drive from San Antonio to Opelousascar car 415.3 mi
    7h 4m
    $76–110

  5. Bus via Houston

    1. Take the bus from San Antonio to Hyatt Regency Galleria Houstonbus bus Houston
    2. Take the bus from Houston - Harrisburg Blvd to Lafayettebus bus Houston
    9h 14m
    $210–243

  6. Fly to Alexandria International Airport, bus

    1. Fly from San Antonio International Airport (SAT) to Alexandria International Airport (AEX)plane plane SAT - AEX
    2. Take the bus from Boyce, LA to Opelousasbus bus
    7h 29m
    $104–441

San Antonio International Airport (SAT) to Lafayette Regional Airport (LFT) flights

Calendar82Weekly Planes
Duration4h 42mAverage Duration
Ticket$63Cheapest Price
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Questions & Answers

Map of how to get from San Antonio to Opelousas.ExpandLaunch map view
  • Distance: 432.1 mi
  • Duration: 7h 43m

What companies run services between San Antonio, TX, USA and Opelousas, LA, USA?

Flixbus USA operates a bus from San Antonio Bus Station to Lafayette 5 times a week. Tickets cost $65–110 and the journey takes 7h 20m. Alternatively, Amtrak operates a train from San Antonio Station to Lafayette Amtrak Station 3 times a week. Tickets cost $130–290 and the journey takes 10h 47m.

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