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How to get fromSan Diego to Buffaloby plane, bus, train, bus (Flixbus, Greyhound), car, or train (Amtrak)

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There are 7 ways to get from San Diego to Buffalo by plane, bus, train, bus (Flixbus, Greyhound), car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from San Diego International Airport (SAN) to Buffalo Niagara International Airport (BUF)plane plane SAN - BUF
    7h 30m
    $186–759

  2. Bus, train

    1. Take the bus from San Diego to Fullerton Amtrak Stationbus bus
    2. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago to Clevelandbus bus
    4. Take the bus from Cleveland to Buffalobus bus
    2d 10h

  3. Bus

    1. Take the bus from San Diego to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Columbusbus bus
    4. Take the bus from Columbus to Buffalobus bus
    2d 15h
    $476–722

  4. Drive  2,532.7 mi

    1. Drive from San Diego to Buffalocar car 2,532.7 mi
    41h 44m
    $463–668

  5. Fly to Toronto Pearson International Airport, bus

    1. Fly from San Diego International Airport (SAN) to Toronto Pearson International Airport (YYZ)plane plane SAN - YYZ
    2. Take the bus from Toronto Pearson Airport to Buffalobus bus
    9h 10m
    $425–944

  6. Fly to Rochester, bus

    1. Fly from San Diego International Airport (SAN) to Rochester (ROC)plane plane SAN - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    8h 59m
    $282–1,059

  7. Train (Amtrak)

    1. Take the train from San Diego to Fullerton Amtrak Stationtrain train
    2. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    2d 10h
    $1,549–2,577

San Diego International Airport (SAN) to Buffalo Niagara International Airport (BUF) flights

Calendar89Weekly Planes
Duration7h 39mAverage Duration
Ticket$180Cheapest Price
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Comparing Your Travel Options

Map of how to get from San Diego to Buffalo.ExpandLaunch map view
  • Distance: 2,202.1 mi
  • Duration: 7h 30m

What companies run services between San Diego, CA, USA and Buffalo, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from San Diego International Airport (SAN) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from San Diego to Buffalo via Los Angeles Union Station, St Louis Bus Station, Columbus, S Grant Ave & E Mound St, S High St & E Rich St, and Columbus in around 2d 15h.

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