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How to get fromSan Diego to Florenceby plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

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There are 6 ways to get from San Diego to Florence by plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from San Diego International Airport (SAN) to Florence Regional Airport (FLO)plane plane SAN - FLO
    7h 16m
    $172–644

  2. Bus

    1. Take the bus from San Diego to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to Dallas Bus Stationbus bus
    3. Take the bus from Dallas Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    2d 12h
    $396–769

  3. Train (Amtrak)

    1. Take the train from San Diego to Fullerton Amtrak Stationtrain train
    2. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Selma Stationtrain train
    5. Take the train from Selma Station to Florence Stationtrain train
    3d 4h
    $1,122–2,426

  4. Drive 2,429 mi

    1. Drive from San Diego to Florencecar car 2,429 mi
    38h 2m
    $444–641

  5. Fly to Fayetteville Municipal Airport, train

    1. Fly from San Diego International Airport (SAN) to Fayetteville Municipal Airport (FAY)plane plane SAN - FAY
    2. Take the train from Fayetteville Amtrak Station to Florence Stationtrain train
    10h 1m
    $205–708

  6. Bus via Ciudad Juárez

    1. Take the bus from Cross Border Express, San Diego to El Pasobus bus Cbx
    2. Take the bus from El Paso Bus Station to Houston Bus Stationbus bus
    3. Take the bus from Houston - Harrisburg Blvd to Atlantabus bus
    4. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    2d 18h
    $425–680

San Diego to Florence by bus

Calendar14Weekly Buses
Duration2d 12hAverage Duration
Ticket$396Cheapest Price
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Questions & Answers

Map of how to get from San Diego to Florence.ExpandLaunch map view
  • Distance: 2,152.3 mi
  • Duration: 7h 16m

What companies run services between San Diego, CA, USA and Florence, SC, USA?

American Airlines flies from San Diego International Airport (SAN) to Florence Regional Airport (FLO) twice daily. Alternatively, you can take a bus from San Diego to Florence Bus Station via Los Angeles Union Station, Dallas Bus Station, and Atlanta Bus Station in around 2d 12h.

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