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How to get fromSan Diego to Florida Keysby plane, train, bus, car, or shuttle

Find Transport to Florida Keys

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There are 5 ways to get from San Diego to Florida Keys by plane, train, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Key West International Airport

    best
    1. Fly from San Diego International Airport (SAN) to Key West International Airport (EYW)plane plane SAN - EYW
    10h 4m
    $222–647

  2. Train, bus

    1. Take the train from San Diego to Fullerton Amtrak Stationtrain train
    2. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4d 3h
    $1,424–3,035

  3. Drive 2,766.6 mi

    1. Drive from San Diego to Florida Keyscar car 2,766.6 mi
    45h 9m
    $505–730

  4. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from San Diego International Airport (SAN) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane SAN - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 45m
    $497–1,225

  5. Fly to Miami International Airport, shuttle

    1. Fly from San Diego International Airport (SAN) to Miami International Airport (MIA)plane plane SAN - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 38m
    $335–638

San Diego to Florida Keys by train, taxi, bus, and foot

Calendar7Weekly Services
Duration4d 3hAverage Duration
Ticket$1,424Cheapest Price
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Questions & Answers

Map of how to get from San Diego to Florida Keys.ExpandLaunch map view
  • Distance: 2,232.2 mi
  • Duration: 10h 4m

What companies run services between San Diego, CA, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from San Diego International Airport (SAN) to Key West International Airport (EYW) every 4 hours.

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