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How to get fromSan Diego to Knoxvilleby plane, bus, train, bus (Greyhound), or car

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There are 7 ways to get from San Diego to Knoxville by plane, bus, train, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from San Diego International Airport (SAN) to Mcghee Tyson Airport (TYS)plane plane SAN - TYS
    6h 22m
    $312–1,097

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from San Diego International Airport (SAN) to Asheville Regional Airport (AVL)plane plane SAN - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    8h 41m
    $174–636

  3. Bus, train

    1. Take the bus from San Diego to Fullerton Amtrak Stationbus bus
    2. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus
    3d 6h
    $1,058–2,042

  4. Bus

    1. Take the bus from San Diego to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus
    3d 11h
    $637–1,142

  5. Drive 2,154.7 mi

    1. Drive from San Diego to Knoxvillecar car 2,154.7 mi
    34h 41m
    $394–568

  6. Fly to Nashville, drive

    1. Fly from San Diego International Airport (SAN) to Nashville (BNA)plane plane SAN - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 44m
    $180–659

  7. Train, bus

    1. Take the train from San Diego to Fullerton Amtrak Stationtrain train
    2. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus
    3d 8h
    $1,171–2,380

San Diego International Airport (SAN) to Mcghee Tyson Airport (TYS) flights

Calendar70Weekly Planes
Duration7h 19mAverage Duration
Ticket$256Cheapest Price
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Questions & Answers

Map of how to get from San Diego to Knoxville.ExpandLaunch map view
  • Distance: 1,911.6 mi
  • Duration: 6h 22m

What companies run services between San Diego, CA, USA and Knoxville, TN, USA?

Southwest Airlines, American Airlines, and two other airlines fly from San Diego International Airport (SAN) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from San Diego to Knoxville via Los Angeles Union Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 3d 11h.

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