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How to get fromSan Diego to Mayo Clinicby plane, bus (Greyhound), train, bus, or car

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There are 5 ways to get from San Diego to Mayo Clinic by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from San Diego International Airport (SAN) to Rochester (RST)plane plane SAN - RST
    8h 26m
    $127–564

  2. Bus

    1. Take the bus from San Diego to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to Tulsa Bus Stationbus bus
    3. Take the bus from Tulsa to St. Paulbus bus
    4. Take the bus from St. Paul to Rochesterbus bus
    2d 5h
    $422–729

  3. Train, bus

    1. Take the train from San Diego to Fullerton Amtrak Stationtrain train
    2. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    2d 8h
    $808–1,697

  4. Drive 1,904.3 mi

    1. Drive from San Diego to Mayo Cliniccar car 1,904.3 mi
    31h 1m
    $348–502

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from San Diego International Airport (SAN) to Minneapolis–Saint Paul International Airport (MSP)plane plane SAN - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 26m
    $266–593

San Diego to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration2d 5hAverage Duration
Ticket$422Cheapest Price
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Questions & Answers

Map of how to get from San Diego to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,546.6 mi
  • Duration: 8h 26m

What companies run services between San Diego, CA, USA and Mayo Clinic, MN, USA?

American Airlines, Delta, and United Airlines fly from San Diego International Airport (SAN) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from San Diego to Mayo Clinic via Los Angeles Union Station, Tulsa, St. Paul, and Rochester in around 2d 5h.

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