There are 4 ways to get from San Diego to Mesa by plane, tram, bus (Greyhound), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly, tram
best- Fly from San Diego International Airport (SAN) to Phoenix (PHX)plane SAN - PHX
- Take the tram from 44th St/Washington to Mesa Dr/Main Sttram
2h 17m$102–332Bus (Greyhound)
cheapest- Take the bus from El Cajon Transit Center to Phoenix Bus Stationbus Greyhound US0851S
9h 53m$54–127Drive 360.5 mi
- Drive from San Diego to Mesacar 360.5 mi
6h 11m$66–95Bus via Cross Border Express, San Diego
- Take the bus from San Diego - Santa Fe Depot to Cross Border Xpressbus 4.1
- Take the bus from Cross Border Express, San Diego to Phoenixbus Cbx
22h 18m$84–129
San Diego to Mesa by tram and bus (Greyhound)
Questions & Answers
The cheapest way to get from San Diego to Mesa is to drive which costs $65 - $95 and takes 6h 11m.
The fastest way to get from San Diego to Mesa is to fly and tram which takes 2h 17m and costs $100 - $340.
No, there is no direct bus from San Diego to Mesa station. However, there are services departing from El Cajon Transit Center and arriving at Phoenix Bus Station via . The journey, including transfers, takes approximately 9h 53m.
The distance between San Diego and Mesa is 320 miles. The road distance is 362.6 miles.
The best way to get from San Diego to Mesa without a car is to bus which takes 9h 53m and costs $50 - $130.
It takes approximately 2h 17m to get from San Diego to Mesa, including transfers.
San Diego to Mesa bus services, operated by Greyhound USA, depart from El Cajon Transit Center station.
San Diego to Mesa bus services, operated by Greyhound USA, arrive at Phoenix Bus Station.
Yes, the driving distance between San Diego to Mesa is 363 miles. It takes approximately 6h 11m to drive from San Diego to Mesa.
Book your San Diego to Mesa bus tickets online with Omio.
What companies run services between San Diego, CA, USA and Mesa, AZ, USA?
Greyhound USA operates a bus from El Cajon Transit Center to Phoenix Bus Station once daily. Tickets cost $50–110 and the journey takes 7h.
- Website
- southwest.com
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $40–270
- Website
- alaskaair.com
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $160–240
- Website
- aa.com
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $40–270
- Website
- flyfrontier.com
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- $90–330
- Phone
- +1 (602) 253-5000
- [email protected]
- Website
- valleymetro.org
Tram from 44th St/Washington to Mesa Dr/Main St
- Ave. Duration
- 41 min
- Frequency
- Every 20 minutes
- Estimated price
- $2
- Website
- https://www.valleymetro.org
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from El Cajon Transit Center to Phoenix Bus Station
- Ave. Duration
- 7h
- Frequency
- Once daily
- Estimated price
- $50–110
- Website
- https://www.greyhound.com/
- Phone
- +1 866 691 9732
- [email protected]
- Website
- eplalimo.com
Bus from San Diego - Santa Fe Depot to Cross Border Xpress
- Ave. Duration
- 10h
- Frequency
- Once daily
- Estimated price
- $17–35
- Website
- https://eplalimo.com/
- One Way
- $23–35
- [email protected]
- Website
- crossborderxpress.com
Bus from Cross Border Express, San Diego to Phoenix
- Ave. Duration
- 10h 20m
- Frequency
- 3 times a day
- Estimated price
- $65–95
- Schedules at
- crossborderxpress.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
There are 2867+ hotels available in Mesa.






