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How to get fromSan Diego to Port Isabelby plane, train, bus, car, or bus (Flixbus, Greyhound)

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There are 8 ways to get from San Diego to Port Isabel by plane, train, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Brownsville-South Padre Island International Airport

    best
    1. Fly from San Diego International Airport (SAN) to Brownsville-South Padre Island International Airport (BRO)plane plane SAN - BRO
    7h 16m
    $92–399

  2. Train, bus via San Antonio

    1. Take the train from San Diego to Los Angelestrain train
    2. Take the train from Los Angeles to San Antonio Stationtrain train
    3. Take the bus from San Antonio to Brownsvillebus bus
    40h 52m
    $903–1,413

  3. Bus via Chihuahua

    1. Take the bus from Tijuana to Chihuahuabus bus
    2. Take the bus from Chihuahua to Matamorosbus bus
    47h 3m
    $292–582

  4. Drive  1,560.6 mi

    1. Drive from San Diego to Port Isabelcar car 1,560.6 mi
    24h 14m
    $258–373

  5. Fly to Mcallen Miller International Airport, bus

    1. Fly from San Diego International Airport (SAN) to Mcallen Miller International Airport (MFE)plane plane SAN - MFE
    2. Take the bus from McAllen Central Station to Brownsvillebus bus
    9h 22m
    $123–417

  6. Fly to Rio Grande Valley International Airport, bus

    1. Fly from San Diego International Airport (SAN) to Rio Grande Valley International Airport (HRL)plane plane SAN - HRL
    2. Take the bus from Harlingen Bus Station to Brownsvillebus bus
    9h 30m
    $121–429

  7. Train, bus

    1. Take the train from San Diego to Los Angelestrain train
    2. Take the train from Los Angeles to San Marcos Amtraktrain train
    3. Take the bus from San Marcos to La Plaza at Brownsvillebus bus
    2d
    $937–1,509

  8. Bus

    1. Take the bus from San Diego to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to Dallas Bus Stationbus bus
    3. Take the bus from Dallas Bus Station to La Plaza at Brownsvillebus bus
    2d 2h
    $382–601

San Diego International Airport (SAN) to Brownsville-South Padre Island International Airport (BRO) flights

Calendar27Weekly Planes
Duration6h 5mAverage Duration
Ticket$89Cheapest Price
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Comparing Your Travel Options

Map of how to get from San Diego to Port Isabel.ExpandLaunch map view
  • Distance: 1,297.7 mi
  • Duration: 7h 16m

What companies run services between San Diego, CA, USA and Port Isabel, TX, USA?

United Airlines and American Airlines fly from San Diego International Airport (SAN) to Brownsville-South Padre Island International Airport (BRO) 4 times a day. Alternatively, you can take a vehicle from Civic Center Station to Las Palmas Port Isabel via San Ysidro Station, San Ysidro, Tijuana, Chihuahua, Matamoros, Brownsville, TX, and La Plaza at Brownsville in around 47h 3m.

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Need to know: Greyhound

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