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How to get fromSan Diego to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), or car

Find Transport to St. Louis

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There are 5 ways to get from San Diego to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from San Diego International Airport (SAN) to Lambert–St. Louis International Airport (STL)plane plane SAN - STL
    4h 13m
    $140–189

  2. Bus

    1. Take the bus from San Diego to Los Angeles Union Stationbus bus FlixBus N2003 / ...
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus Greyhound US1210
    43h 45m
    $370–579

  3. Train via Kansas City (Amtrak)

    1. Take the train from San Diego to Fullerton Amtrak Stationtrain train
    2. Take the train from Fullerton Amtrak Station to Kansas Citytrain train
    3. Take the train from Kansas City to St. Louistrain train
    44h 30m
    $1,156–1,827

  4. Drive  1,796.6 mi

    1. Drive from San Diego to St. Louiscar car 1,796.6 mi
    29h 10m
    $318–459

  5. Train (Amtrak)

    1. Take the train from San Diego to Los Angelestrain train Pacific Surfliner
    2. Take the train from Los Angeles to St. Louistrain train Texas Eagle
    2d 11h
    $1,370–2,207

San Diego to St. Louis by bus

Calendar7Weekly Buses
Duration43h 45mAverage Duration
Ticket$370Cheapest Price
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Comparing Your Travel Options

Map of how to get from San Diego to St. Louis.ExpandLaunch map view
  • Distance: 1,568.7 mi
  • Duration: 4h 13m

What companies run services between San Diego, CA, USA and St. Louis, MO, USA?

Southwest Airlines and American Airlines fly from San Diego International Airport (SAN) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from San Diego to St Louis Bus Station via Los Angeles Union Station in around 43h 45m.

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