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How to get fromSan Diego to St. Louisby plane, bus (Greyhound), train (Amtrak), or car

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There are 5 ways to get from San Diego to St. Louis by plane, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from San Diego International Airport (SAN) to Lambert–St. Louis International Airport (STL)plane plane SAN - STL
    4h 23m
    $140–189

  2. Bus

    1. Take the bus from San Diego to Los Angeles Union Stationbus bus Tijuana
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus Greyhound US1210
    44h 10m
    $324–638

  3. Train via Kansas City (Amtrak)

    1. Take the train from San Diego to Fullerton Amtrak Stationtrain train
    2. Take the train from Fullerton Amtrak Station to Kansas Citytrain train
    3. Take the train from Kansas City to St. Louistrain train
    44h 30m
    $673–1,457

  4. Drive 1,796.6 mi

    1. Drive from San Diego to St. Louiscar car 1,796.6 mi
    29h 10m
    $328–474

  5. Train (Amtrak)

    1. Take the train from San Diego to Los Angelestrain train Pacific Surfliner
    2. Take the train from Los Angeles to St. Louistrain train Texas Eagle
    2d 11h
    $791–1,683

San Diego to St. Louis by bus

Calendar21Weekly Buses
Duration44h 10mAverage Duration
Ticket$324Cheapest Price
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Questions & Answers

Map of how to get from San Diego to St. Louis.ExpandLaunch map view
  • Distance: 1,568.7 mi
  • Duration: 4h 23m

What companies run services between San Diego, CA, USA and St. Louis, MO, USA?

Southwest Airlines, United Airlines, and American Airlines fly from San Diego International Airport (SAN) to Lambert–St. Louis International Airport (STL) 5 times a day. Alternatively, you can take a bus from San Diego to St Louis Bus Station via Los Angeles Union Station in around 44h 10m.

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