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How to get fromSan Francisco to Florenceby plane, bus (Flixbus, Greyhound), train, bus, or car

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There are 4 ways to get from San Francisco to Florence by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from San Francisco International Airport (SFO) to Florence Regional Airport (FLO)plane plane SFO - FLO
    9h 1m
    $170–625

  2. Bus

    1. Take the bus from San Francisco to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to Dallas Bus Stationbus bus
    3. Take the bus from Dallas Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    2d 17h
    $442–845

  3. Train, bus

    1. Take the train from Richmond to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    3d 11h
    $1,120–2,403

  4. Drive 2,744.9 mi

    1. Drive from San Francisco to Florencecar car 2,744.9 mi
    44h 1m
    $501–724

San Francisco to Florence by bus

Calendar8Weekly Buses
Duration2d 17hAverage Duration
Ticket$442Cheapest Price
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Questions & Answers

Map of how to get from San Francisco to Florence.ExpandLaunch map view
  • Distance: 2,395 mi
  • Duration: 9h 1m

What companies run services between San Francisco, CA, USA and Florence, SC, USA?

American Airlines flies from San Francisco International Airport (SFO) to Florence Regional Airport (FLO) twice daily. Alternatively, you can take a bus from San Francisco to Florence Bus Station via Los Angeles Union Station, Dallas Bus Station, and Atlanta Bus Station in around 2d 17h.

Airlines
Train operators
Bus operators

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