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How to get fromSan Francisco to Knoxvilleby plane, train, bus, bus (Flixbus, Greyhound), or car

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There are 9 ways to get from San Francisco to Knoxville by plane, train, bus, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly San Francisco International Airport to Mcghee Tyson Airport

    best
    1. Fly from San Francisco International Airport (SFO) to Mcghee Tyson Airport (TYS)plane plane SFO - TYS
    8h 14m
    $315–1,082

  2. Fly San Francisco International Airport to Nashville, drive

    cheapest
    1. Fly from San Francisco International Airport (SFO) to Nashville (BNA)plane plane SFO - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    8h 41m
    $250–532

  3. Train, bus via Farragut

    1. Take the train from Richmond to Chicago Union Stationtrain train
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus
    3d 13h
    $1,078–2,099

  4. Bus

    1. Take the bus from San Francisco to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus
    3d 17h
    $680–1,213

  5. Drive 2,464.5 mi

    1. Drive from San Francisco to Knoxvillecar car 2,464.5 mi
    39h 18m
    $450–650

  6. Fly Oakland International Airport to Mcghee Tyson Airport

    1. Fly from Oakland International Airport (OAK) to Mcghee Tyson Airport (TYS)plane plane OAK - TYS
    8h 12m
    $361–1,278

  7. Caltrain to Norman Y. Mineta San José International Airport, fly to Mcghee Tyson Airport

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to Mcghee Tyson Airport (TYS)plane plane SJC - TYS
    9h 26m
    $347–1,284

  8. Train to Sacramento International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Richmond to Sacramentotrain train
    2. Fly from Sacramento International Airport (SMF) to Mcghee Tyson Airport (TYS)plane plane SMF - TYS
    11h 27m
    $386–1,335

  9. Train, bus

    1. Take the train from Richmond to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus
    3d 16h
    $1,193–2,419

San Francisco International Airport (SFO) to Mcghee Tyson Airport (TYS) flights

Calendar86Weekly Planes
Duration7h 36mAverage Duration
Ticket$249Cheapest Price
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Questions & Answers

Map of how to get from San Francisco to Knoxville.ExpandLaunch map view
  • Distance: 2,142.4 mi
  • Duration: 8h 14m

What companies run services between San Francisco, CA, USA and Knoxville, TN, USA?

Delta, United Airlines, and two other airlines fly from San Francisco International Airport (SFO) to Mcghee Tyson Airport (TYS) every 2 hours. Alternatively, you can take a bus from San Francisco to Knoxville via Los Angeles Union Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 3d 17h.

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