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How to get fromSan Francisco to La Crosseby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

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There are 8 ways to get from San Francisco to La Crosse by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly San Francisco International Airport to La Crosse

    best
    1. Fly from San Francisco International Airport (SFO) to La Crosse (LSE)plane plane SFO - LSE
    8h 25m
    $159–585

  2. Fly San Francisco International Airport to Rochester, bus

    cheapest
    1. Fly from San Francisco International Airport (SFO) to Rochester (RST)plane plane SFO - RST
    2. Take the bus from Rochester to La Crossebus bus
    11h 52m
    $149–572

  3. Bus

    1. Take the bus from San Francisco Bus Station to Sparks Transit Centerbus bus
    2. Take the bus from Sparks Transit Center to Denver Union Stationbus bus
    3. Take the bus from Denver Union Station to Chicago Bus Stationbus bus
    4. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    5. Take the bus from Milwaukee to La Crossebus bus
    2d 8h
    $398–756

  4. Train (Amtrak)

    1. Take the train from Richmond to Chicago Union Stationtrain train California Zephyr
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    2d 11h
    $840–1,796

  5. Drive 1,994.9 mi

    1. Drive from San Francisco to La Crossecar car 1,994.9 mi
    32h 27m
    $365–526

  6. Fly San Francisco International Airport to Minneapolis–Saint Paul International Airport, train

    1. Fly from San Francisco International Airport (SFO) to Minneapolis–Saint Paul International Airport (MSP)plane plane SFO - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    9h 28m
    $172–420

  7. Caltrain to Norman Y. Mineta San José International Airport, fly to Minneapolis–Saint Paul International Airport, train

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to Minneapolis–Saint Paul International Airport (MSP)plane plane SJC - MSP
    3. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    10h 37m
    $494–752

  8. Caltrain to Norman Y. Mineta San José International Airport, fly to Rochester, bus

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to Rochester (RST)plane plane SJC - RST
    3. Take the bus from Rochester to La Crossebus bus
    13h 42m
    $171–644

San Francisco to La Crosse by bus

Calendar7Weekly Buses
Duration2d 8hAverage Duration
Ticket$398Cheapest Price
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Questions & Answers

Map of how to get from San Francisco to La Crosse.ExpandLaunch map view
  • Distance: 1,696.2 mi
  • Duration: 8h 25m

What companies run services between San Francisco, CA, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from San Francisco International Airport (SFO) to La Crosse (LSE) every 4 hours. Alternatively, you can take a bus from San Francisco Bus Station to La Crosse via Sparks Transit Center, Denver Union Station, Chicago Bus Station, Milwaukee Intermodal Station, and Milwaukee in around 2d 8h.

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