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How to get fromSan Francisco to La Mesaby plane, tram, subway, bus, train, train (Amtrak), car, shuttle, or bus (Greyhound)

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There are 9 ways to get from San Francisco to La Mesa by plane, tram, subway, bus, train, train (Amtrak), car, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from San Francisco International Airport, tram

    best
    1. Fly from San Francisco International Airport (SFO) to San Diego International Airport (SAN)plane plane SFO - SAN
    2. Take the tram from Civic Center Station to La Mesa Blvd Stationtram tram
    4h 23m
    $74–262

  2. BART, bus, train

    1. Take the subway from Civic Center / UN Plaza to Berryessa / North San Josesubway subway
    2. Take the bus from San Jose, CA - Huong Lan Sandwich to Los Angeles, CA - Chinatown Stationbus bus
    3. Take the train from Los Angeles to San Diego Old Town Transportation Centertrain train
    12h 44m
    $94–177

  3. Caltrain, train

    1. Take the train from San Francisco Caltrain Southbound to San Jose Diridon Caltrain Southboundtrain train
    2. Take the train from San Jose to Los Angelestrain train
    3. Take the train from Los Angeles to San Diegotrain train
    17h 50m
    $182–392

  4. Drive 504 mi

    1. Drive from San Francisco to La Mesacar car 504 mi
    8h 27m
    $92–133

  5. Fly from Oakland International Airport, tram

    1. Fly from Oakland International Airport (OAK) to San Diego International Airport (SAN)plane plane OAK - SAN
    2. Take the tram from Civic Center Station to La Mesa Blvd Stationtram tram
    4h 27m
    $85–288

  6. Caltrain to Norman Y. Mineta San José International Airport, fly

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to San Diego International Airport (SAN)plane plane SJC - SAN
    5h 21m
    $86–534

  7. Shuttle to Sonoma County Airport, fly

    1. Take a shuttle bus from San Francisco Pier 27 to Santa Rosa Airportshuttle bus
    2. Fly from Sonoma County Airport (STS) to San Diego International Airport (SAN)plane plane STS - SAN
    5h 51m
    $169–320

  8. BART, bus

    1. Take the subway from Civic Center / UN Plaza to Berryessa / North San Josesubway subway Green-N
    2. Take the bus from San Jose - King Rd to San Ysidrobus bus San Jose
    13h 53m
    $105–165

  9. Bus (Greyhound)

    1. Take the bus from San Francisco Bus Station to San Diego Greyhound Bus Stopbus bus Greyhound US0831
    14h 54m
    $84–160

San Francisco to La Mesa by subway, bus, train, and tram

Calendar7Weekly Services
Duration12h 44mAverage Duration
Ticket$94Cheapest Price
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Questions & Answers

Map of how to get from San Francisco to La Mesa.ExpandLaunch map view
  • Distance: 478.2 mi
  • Duration: 4h 23m

What companies run services between San Francisco, CA, USA and La Mesa, CA, USA?

You can take a train from San Francisco Caltrain Southbound to La Mesa Blvd Station via San Jose Diridon Caltrain Southbound, San Jose, Los Angeles, San Diego, and Courthouse Station in around 17h 50m. Alternatively, Greyhound USA operates a bus from San Francisco Bus Station to San Diego Greyhound Bus Stop twice daily. Tickets cost $75–150 and the journey takes 13h 15m.

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