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How to get fromSan Francisco to Mayo Clinicby plane, bus (Flixbus, Greyhound), train, bus, or car

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There are 9 ways to get from San Francisco to Mayo Clinic by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly San Francisco International Airport to Rochester

    best
    1. Fly from San Francisco International Airport (SFO) to Rochester (RST)plane plane SFO - RST
    9h 3m
    $121–532

  2. Bus

    1. Take the bus from San Francisco to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to Tulsa Bus Stationbus bus
    3. Take the bus from Tulsa to St. Paulbus bus
    4. Take the bus from St. Paul to Rochesterbus bus
    2d 12h
    $465–800

  3. Train, bus via Portland

    1. Take the train from Oakland to Portlandtrain train
    2. Take the train from Portland to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    2d 13h
    $811–1,724

  4. Drive 1,932.6 mi

    1. Drive from San Francisco to Mayo Cliniccar car 1,932.6 mi
    31h 26m
    $353–510

  5. Fly San Francisco International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from San Francisco International Airport (SFO) to Minneapolis–Saint Paul International Airport (MSP)plane plane SFO - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 53m
    $182–384

  6. Caltrain to Norman Y. Mineta San José International Airport, fly to Rochester

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to Rochester (RST)plane plane SJC - RST
    10h 54m
    $143–604

  7. Caltrain to Norman Y. Mineta San José International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to Minneapolis–Saint Paul International Airport (MSP)plane plane SJC - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 2m
    $504–716

  8. Fly Oakland International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Oakland International Airport (OAK) to Minneapolis–Saint Paul International Airport (MSP)plane plane OAK - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 42m
    $218–760

  9. Train, bus

    1. Take the train from Richmond to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    2d 15h
    $830–1,736

San Francisco to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration2d 12hAverage Duration
Ticket$465Cheapest Price
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Questions & Answers

Map of how to get from San Francisco to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,637.4 mi
  • Duration: 9h 3m

What companies run services between San Francisco, CA, USA and Mayo Clinic, MN, USA?

United Airlines, Delta, and two other airlines fly from San Francisco International Airport (SFO) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from San Francisco to Mayo Clinic via Los Angeles Union Station, Tulsa, St. Paul, and Rochester in around 2d 12h.

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