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How to get fromSan Francisco to Otay Mesaby plane, tram, bus, subway, train (Amtrak), car, train, shuttle, or bus (Greyhound)

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There are 9 ways to get from San Francisco to Otay Mesa by plane, tram, bus, subway, train (Amtrak), car, train, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from San Francisco International Airport, tram, line 905 bus

    best
    1. Fly from San Francisco International Airport (SFO) to San Diego International Airport (SAN)plane plane SFO - SAN
    2. Take the tram from Civic Center Station to Iris Avenue Stationtram tram
    3. Take the bus from Iris Avenue Transit Center to Otay Mesa Rd & Cactus Rdbus bus
    4h 39m
    $76–266

  2. BART, bus

    1. Take the subway from Civic Center / UN Plaza to Berryessa / North San Josesubway subway Green-N
    2. Take the bus from San Jose - King Rd to San Ysidrobus bus San Jose
    13h 10m
    $103–141

  3. Train (Amtrak)

    1. Take the train from Oakland to Simi Valley Amtraktrain train Coast Starlight
    2. Take the train from Simi Valley Amtrak to San Diego Old Town Transportation Centertrain train Pacific Surfliner
    18h 56m
    $187–421

  4. Drive 517.1 mi

    1. Drive from San Francisco to Otay Mesacar car 517.1 mi
    8h 42m
    $95–137

  5. BART to Oakland International Airport, fly, tram, line 905 bus

    1. Take the subway from Powell Street to Coliseumsubway subway
    2. Fly from Oakland International Airport (OAK) to San Diego International Airport (SAN)plane plane OAK - SAN
    3. Take the tram from Civic Center Station to Iris Avenue Stationtram tram
    4. Take the bus from Iris Avenue Transit Center to Otay Mesa Rd & Cactus Rdbus bus
    4h 43m
    $87–292

  6. Caltrain to Norman Y. Mineta San José International Airport, fly

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to San Diego International Airport (SAN)plane plane SJC - SAN
    5h 38m
    $88–538

  7. Shuttle to Sonoma County Airport, fly

    1. Take a shuttle bus from San Francisco Pier 27 to Santa Rosa Airportshuttle bus
    2. Fly from Sonoma County Airport (STS) to San Diego International Airport (SAN)plane plane STS - SAN
    6h 7m
    $171–324

  8. Bus (Greyhound)

    1. Take the bus from San Francisco Bus Station to San Ysidro Bus Terminalbus bus Greyhound US0831
    14h 26m
    $85–160

  9. Bus, tram

    1. Take the bus from San Francisco to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to San Diegobus bus
    3. Take the tram from UCSD Health La Jolla Station to Iris Avenue Stationtram tram
    15h 4m
    $89–165

San Francisco to Otay Mesa by subway, bus, and tram

Calendar14Weekly Services
Duration13h 10mAverage Duration
Ticket$103Cheapest Price
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Questions & Answers

Map of how to get from San Francisco to Otay Mesa.ExpandLaunch map view
  • Distance: 483.9 mi
  • Duration: 4h 39m

What companies run services between San Francisco, CA, USA and Otay Mesa, CA, USA?

You can take a subway from Civic Center / UN Plaza to Otay Mesa Rd & Cactus Rd via Lake Merritt, Oakland, Simi Valley Amtrak, San Diego Old Town Transportation Center, Old Town Station, Iris Avenue Station, and Iris Avenue Transit Center in around 18h 56m. Alternatively, Greyhound USA operates a bus from San Francisco Bus Station to San Ysidro Bus Terminal twice daily. Tickets cost $80–160 and the journey takes 13h 50m.

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