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How to get fromSan Francisco to Santa Anaby plane, bus (Flixbus), train (Amtrak), car, train, subway, bus, or bus (Greyhound)

Find Transport to Santa Ana

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There are 8 ways to get from San Francisco to Santa Ana by plane, bus (Flixbus), train (Amtrak), car, train, subway, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from San Francisco International Airport

    best
    1. Fly from San Francisco International Airport (SFO) to John Wayne Airport Orange County (SNA)plane plane SFO - SNA
    3h 9m
    $139–377

  2. Bus via Artic - Dock 4 (Flixbus)

    cheapest
    1. Take the bus from San Francisco to Anaheim Regional Transportation Intermodal Centerbus bus FlixBus N2003
    9h 38m
    $69–100

  3. Caltrain, train

    1. Take the train from San Francisco Caltrain Southbound to San Jose Diridon Caltrain Southboundtrain train
    2. Take the train from San Jose to Los Angelestrain train
    3. Take the train from Los Angeles to Santa Anatrain train
    14h 47m
    $259–402

  4. Drive  413 mi

    1. Drive from San Francisco to Santa Anacar car 413 mi
    6h 53m
    $76–109

  5. Fly from Oakland International Airport

    1. Fly from Oakland International Airport (OAK) to John Wayne Airport Orange County (SNA)plane plane OAK - SNA
    3h 10m
    $245–793

  6. Caltrain to Norman Y. Mineta San José International Airport, fly

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to John Wayne Airport Orange County (SNA)plane plane SJC - SNA
    4h 5m
    $411–849

  7. BART, bus, train

    1. Take the subway from Civic Center / UN Plaza to Berryessa / North San Josesubway subway
    2. Take the bus from San Jose, CA - Huong Lan Sandwich to Los Angeles, CA - Chinatown Stationbus bus
    3. Take the train from Los Angeles to Santa Anatrain train
    10h 15m
    $76–108

  8. Bus (Greyhound)

    1. Take the bus from San Francisco Bus Station to Santa Ana Bus Stopbus bus Greyhound US0831
    11h 30m
    $75–120

San Francisco to Santa Ana by bus (Flixbus)

Calendar7Weekly Buses
Duration9h 38mAverage Duration
Ticket$69Cheapest Price
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Comparing Your Travel Options

Map of how to get from San Francisco to Santa Ana.ExpandLaunch map view
  • Distance: 391.9 mi
  • Duration: 3h 9m

What companies run services between San Francisco, CA, USA and Santa Ana, CA, USA?

Alaska Airlines, Inc., Frontier Airlines, and United Airlines fly from San Francisco International Airport (SFO) to John Wayne Airport Orange County (SNA) hourly. Alternatively, Flixbus USA operates a bus from San Francisco to Anaheim Regional Transportation Intermodal Center once daily. Tickets cost $65–100 and the journey takes 9h 5m.

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