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How to get fromSan Francisco to Santa Fe Depotby plane, subway, bus, train, train (Amtrak), car, shuttle, or bus (Greyhound)

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There are 9 ways to get from San Francisco to Santa Fe Depot by plane, subway, bus, train, train (Amtrak), car, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from San Francisco International Airport

    best
    1. Fly from San Francisco International Airport (SFO) to San Diego International Airport (SAN)plane plane SFO - SAN
    3h 31m
    $72–247

  2. BART, bus, train

    1. Take the subway from Civic Center / UN Plaza to Berryessa / North San Josesubway subway
    2. Take the bus from San Jose, CA - Huong Lan Sandwich to Los Angeles, CA - Chinatown Stationbus bus
    3. Take the train from Los Angeles to San Diegotrain train
    12h 22m
    $97–163

  3. Caltrain, train

    1. Take the train from San Francisco Caltrain Southbound to San Jose Diridon Caltrain Southboundtrain train
    2. Take the train from San Jose to Los Angelestrain train
    3. Take the train from Los Angeles to San Diegotrain train
    16h 54m
    $180–377

  4. Drive 500.7 mi

    1. Drive from San Francisco to Santa Fe Depotcar car 500.7 mi
    8h 25m
    $92–132

  5. BART to Oakland International Airport, fly

    1. Take the subway from Powell Street to Coliseumsubway subway
    2. Fly from Oakland International Airport (OAK) to San Diego International Airport (SAN)plane plane OAK - SAN
    3h 35m
    $83–273

  6. Caltrain to Norman Y. Mineta San José International Airport, fly

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to San Diego International Airport (SAN)plane plane SJC - SAN
    4h 30m
    $84–519

  7. Shuttle to Sonoma County Airport, fly

    1. Take a shuttle bus from San Francisco Pier 27 to Santa Rosa Airportshuttle bus
    2. Fly from Sonoma County Airport (STS) to San Diego International Airport (SAN)plane plane STS - SAN
    4h 58m
    $167–305

  8. BART, bus

    1. Take the subway from Civic Center / UN Plaza to Berryessa / North San Josesubway subway Green-N
    2. Take the bus from San Jose - King Rd to San Ysidrobus bus San Jose
    13h 24m
    $103–151

  9. Bus (Greyhound)

    1. Take the bus from San Francisco Bus Station to San Diego Greyhound Bus Stopbus bus Greyhound US0831
    13h 28m
    $80–160

San Francisco to Santa Fe Depot by subway, bus, and train

Calendar7Weekly Services
Duration12h 22mAverage Duration
Ticket$97Cheapest Price
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Questions & Answers

Map of how to get from San Francisco to Santa Fe Depot.ExpandLaunch map view
  • Distance: 465.7 mi
  • Duration: 3h 31m

What companies run services between San Francisco, CA, USA and Santa Fe Depot, San Diego County, CA, USA?

Alaska Airlines, Inc., Frontier Airlines, and two other airlines fly from San Francisco International Airport (SFO) to San Diego International Airport (SAN) hourly. Alternatively, you can take a train from San Francisco Caltrain Southbound to San Diego via San Jose Diridon Caltrain Southbound, San Jose, and Los Angeles in around 16h 54m.

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