There are 9 ways to get from San Luis Obispo to Calexico by bus (Flixbus), train, bus, car, plane, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus (Flixbus)
best- Take the bus from San Luis Obispo Railroad Museum to Los Angeles Union Stationbus FlixBus 2005
- Take the bus from Los Angeles Downtown to Calexico Bus Stationbus FlixBus 2054
10h 30m$65–109Fly San Luis Obispo County Regional Airport to Yuma International Airport, bus
cheapest- Fly from San Luis Obispo County Regional Airport (SBP) to Yuma International Airport (YUM)plane SBP - YUM
- Take the bus from Yuma County Area Transit to Calexico Bus Stationbus
9h 19m$60–312Train, bus
- Take the train from San Luis Obispo to San Diego Old Town Transportation Centertrain Pacific Surfliner
- Take the bus from San Diego Greyhound Bus Stop to Calexico Bus Stationbus Greyhound US0851S
12h 25m$129–267Drive 406.4 mi
- Drive from San Luis Obispo to Calexicocar 406.4 mi
7h 14m$75–108Fly San Luis Obispo County Regional Airport to San Diego International Airport, bus
- Fly from San Luis Obispo County Regional Airport (SBP) to San Diego International Airport (SAN)plane SBP - SAN
- Take the bus from San Diego Greyhound Bus Stop to Calexico Bus Stationbus
7h$190–392Bus via Santa Maria Airport (SMX)
- Take the bus from Government Center to Santa Maria Transit Centerbus 10S
- Take the bus from Santa Maria Airport, CA to Los Angeles Airport, CAbus
- Take the bus from Los Angeles Union Station to Calexico Bus Stationbus
13h 33m$126–183Train to Los Angeles International Airport, fly to Imperial County Airport
- Take the train from San Luis Obispo to Los Angelestrain
- Fly from Los Angeles International Airport (LAX) to Imperial County Airport (IPL)plane LAX - IPL
9h 23m$193–639Fly San Luis Obispo County Regional Airport to Imperial County Airport
- Fly from San Luis Obispo County Regional Airport (SBP) to Imperial County Airport (IPL)plane SBP - IPL
7h 28m$90–352Bus to Santa Barbara Municipal Airport, fly to San Diego International Airport, bus
- Take the bus from San Luis Obispo to Uc Santa Barbara Amtrak Bus Stopbus
- Fly from Santa Barbara Municipal Airport (SBA) to San Diego International Airport (SAN)plane SBA - SAN
- Take the bus from San Diego Greyhound Bus Stop to Calexico Bus Stationbus
8h 54m$215–311
San Luis Obispo to Calexico by bus (Flixbus)
Questions & Answers
The cheapest way to get from San Luis Obispo to Calexico is to bus which costs $60 - $110 and takes 10h 30m.
The fastest way to get from San Luis Obispo to Calexico is to fly and bus which takes 7h and costs $190 - $400.
No, there is no direct bus from San Luis Obispo to Calexico station. However, there are services departing from San Luis Obispo Railroad Museum and arriving at Calexico Bus Station via Los Angeles Downtown. The journey, including transfers, takes approximately 10h 30m.
The distance between San Luis Obispo and Calexico is 412 miles. The road distance is 408.7 miles.
The best way to get from San Luis Obispo to Calexico without a car is to bus which takes 10h 30m and costs $60 - $110.
It takes approximately 10h 30m to get from San Luis Obispo to Calexico, including transfers.
San Luis Obispo to Calexico bus services, operated by Flixbus USA, depart from San Luis Obispo Railroad Museum station.
The best way to get from San Luis Obispo to Calexico is to bus which takes 10h 30m and costs $60 - $110. Alternatively, you can fly, which costs $90 - $360 and takes 7h 28m.
San Luis Obispo to Calexico bus services, operated by Flixbus USA, arrive at Los Angeles Union Station.
Yes, the driving distance between San Luis Obispo to Calexico is 409 miles. It takes approximately 7h 14m to drive from San Luis Obispo to Calexico.
What companies run services between San Luis Obispo, CA, USA and Calexico, CA, USA?
You can take a bus from San Luis Obispo Railroad Museum to Calexico Bus Station via Los Angeles Union Station and Los Angeles Downtown in around 10h 30m. Alternatively, United Airlines, Southern Airways Express, and American Airlines fly from San Luis Obispo County Regional Airport (SBP) to Imperial County Airport (IPL) 4 times a day.
- Website
- iflysouthern.com
Flights from Los Angeles International Airport to Imperial County Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- $80–230
Flights from San Luis Obispo County Regional Airport to Imperial County Airport via Los Angeles International Airport
- Ave. Duration
- 6h 26m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $110–330
Flights from San Luis Obispo County Regional Airport to Imperial County Airport via Phoenix
- Ave. Duration
- 7h 53m
- When
- Every day
- Estimated price
- $60–310
Flights from San Luis Obispo County Regional Airport to Imperial County Airport via San Francisco, Los Angeles International Airport
- Ave. Duration
- 8h 55m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $60–310
- Website
- alaskaair.com
Flights from San Luis Obispo County Regional Airport to San Diego International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $170–350
Flights from Santa Barbara Municipal Airport to San Diego International Airport
- Ave. Duration
- 1h 4m
- When
- Every day
- Estimated price
- $160–220
Flights from San Luis Obispo County Regional Airport to Yuma International Airport via San Diego International Airport, Phoenix
- Ave. Duration
- 6h 34m
- When
- Sunday
- Estimated price
- $140–750
- Website
- aa.com
Flights from San Luis Obispo County Regional Airport to San Diego International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $170–350
Flights from San Luis Obispo County Regional Airport to Yuma International Airport via Phoenix
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $50–290
- Website
- southwest.com
Flights from Santa Barbara Municipal Airport to San Diego International Airport
- Ave. Duration
- 53 min
- When
- Every day
- Estimated price
- $30–220
- Website
- united.com
Flights from San Luis Obispo County Regional Airport to San Diego International Airport via Los Angeles International Airport
- Ave. Duration
- 3h 28m
- When
- Saturday, Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $35–240
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from San Luis Obispo to San Diego Old Town Transportation Center
- Ave. Duration
- 8h 40m
- Frequency
- 3 times a day
- Estimated price
- $110–230
- Website
- Amtrak
Train from San Luis Obispo to Los Angeles
- Ave. Duration
- 5h 38m
- Frequency
- 4 times a day
- Estimated price
- $70–150
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from San Luis Obispo Railroad Museum to Los Angeles Union Station
- Ave. Duration
- 4h 15m
- Frequency
- Once daily
- Estimated price
- $29–50
- Schedules at
- Flixbus USA
Bus from Los Angeles Downtown to Calexico Bus Station
- Ave. Duration
- 5h 15m
- Frequency
- Twice daily
- Estimated price
- $35–60
- Schedules at
- Flixbus USA
Bus from Los Angeles Union Station to Calexico Bus Station
- Ave. Duration
- 5h 5m
- Frequency
- Twice daily
- Estimated price
- $35–60
- Schedules at
- Flixbus USA
Bus from Yuma County Area Transit to Calexico Bus Station
- Ave. Duration
- 1h 10m
- Frequency
- Twice daily
- Estimated price
- $9–15
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from San Diego Greyhound Bus Stop to Calexico Bus Station
- Ave. Duration
- 2h 45m
- Frequency
- Twice daily
- Estimated price
- $19–40
- Website
- Greyhound
Bus from San Diego Greyhound Bus Stop to Calexico Bus Station
- Ave. Duration
- 2h 45m
- Frequency
- Twice daily
- Estimated price
- $19–40
- Website
- Greyhound
Bus from Los Angeles Union Station to Calexico Bus Station
- Ave. Duration
- 6h 25m
- Frequency
- Twice daily
- Estimated price
- $30–65
- Website
- Greyhound
Bus from San Diego Greyhound Bus Stop to Calexico Bus Station
- Ave. Duration
- 2h 45m
- Frequency
- Twice daily
- Estimated price
- $19–40
- Website
- Greyhound
Bus from Yuma County Area Transit to Calexico Bus Station
- Ave. Duration
- 1h
- Frequency
- 4 times a day
- Estimated price
- $8–16
- Website
- Greyhound
- Website
- SoCoTransit
Bus from Government Center to Santa Maria Transit Center
- Ave. Duration
- 1h 4m
- Frequency
- Every 2 hours
- Estimated price
- $2–4
- Website
- SoCoTransit
- Phone
- +1 800-470-8818
- [email protected]
- Website
- Central Coast Shuttle
Bus from Santa Maria Airport, CA to Los Angeles Airport, CA
- Ave. Duration
- 3h 45m
- Frequency
- Every 4 hours
- Estimated price
- $85–105
- Website
- Central Coast Shuttle
- one way non-prepaid
- $90–105
- One-way prepaid 48 hours advance
- $85–100
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from San Luis Obispo to Uc Santa Barbara Amtrak Bus Stop
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- $30–50
- Website
- Amtrak
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Book your San Luis Obispo to Calexico bus tickets online with Omio and FlixBus.
There are 95+ hotels available in Calexico.









