Rome2Rio

How to get fromSan Luis Obispo to Knoxvilleby plane, bus (Flixbus, Greyhound), train, bus, or car

Find Transport to Knoxville

See all options

There are 7 ways to get from San Luis Obispo to Knoxville by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly San Luis Obispo County Regional Airport to Mcghee Tyson Airport

    best
    1. Fly from San Luis Obispo County Regional Airport (SBP) to Mcghee Tyson Airport (TYS)plane plane SBP - TYS
    8h 13m
    $276–972

  2. Fly San Luis Obispo County Regional Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from San Luis Obispo County Regional Airport (SBP) to Asheville Regional Airport (AVL)plane plane SBP - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    10h 5m
    $152–586

  3. Bus

    1. Take the bus from San Luis Obispo Railroad Museum to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus
    3d 12h
    $642–1,150

  4. Train, bus

    1. Take the train from San Luis Obispo to Fullerton Amtrak Stationtrain train
    2. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus
    3d 13h
    $1,165–2,475

  5. Drive 2,302.6 mi

    1. Drive from San Luis Obispo to Knoxvillecar car 2,302.6 mi
    37h 4m
    $421–607

  6. Bus to Santa Barbara Municipal Airport, fly to Mcghee Tyson Airport

    1. Take the bus from San Luis Obispo to Uc Santa Barbara Amtrak Bus Stopbus bus
    2. Fly from Santa Barbara Municipal Airport (SBA) to Mcghee Tyson Airport (TYS)plane plane SBA - TYS
    10h 2m
    $301–971

  7. Fly San Luis Obispo County Regional Airport to Chattanooga Metropolitan Airport, drive

    1. Fly from San Luis Obispo County Regional Airport (SBP) to Chattanooga Metropolitan Airport (CHA)plane plane SBP - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    9h 43m
    $248–980

San Luis Obispo County Regional Airport (SBP) to Mcghee Tyson Airport (TYS) flights

Calendar26Weekly Planes
Duration7h 25mAverage Duration
Ticket$224Cheapest Price
See schedules

Questions & Answers

Map of how to get from San Luis Obispo to Knoxville.ExpandLaunch map view
  • Distance: 2,067.4 mi
  • Duration: 8h 13m

What companies run services between San Luis Obispo, CA, USA and Knoxville, TN, USA?

United Airlines, American Airlines, and two other airlines fly from San Luis Obispo County Regional Airport (SBP) to Mcghee Tyson Airport (TYS) 4 times a day. Alternatively, you can take a bus from San Luis Obispo Railroad Museum to Knoxville via Los Angeles Union Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 3d 12h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers