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How to get fromSan Luis Obispo to Santa Anaby bus (Flixbus, Amtrak), train (Amtrak), car, plane, or train

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There are 6 ways to get from San Luis Obispo to Santa Ana by bus (Flixbus, Amtrak), train (Amtrak), car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from San Luis Obispo Railroad Museum to Los Angeles Union Stationbus bus FlixBus 2005
    2. Take the bus from Los Angeles to Santa Anabus bus Amtrak Thruway Connecting Service
    6h 25m
    $42–68

  2. Drive 217.4 mi

    cheapest
    1. Drive from San Luis Obispo to Santa Anacar car 217.4 mi
    4h 2m
    $40–58

  3. Train (Amtrak)

    1. Take the train from San Luis Obispo to Santa Anatrain train Pacific Surfliner
    6h 48m
    $80–170

  4. Fly San Luis Obispo County Regional Airport to Los Angeles International Airport, train

    1. Fly from San Luis Obispo County Regional Airport (SBP) to Los Angeles International Airport (LAX)plane plane SBP - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    5h 25m
    $238–478

  5. Fly San Luis Obispo County Regional Airport to San Diego International Airport, train

    1. Fly from San Luis Obispo County Regional Airport (SBP) to San Diego International Airport (SAN)plane plane SBP - SAN
    2. Take the train from San Diego to Santa Anatrain train
    6h 4m
    $202–422

  6. Train to Norman Y. Mineta San José International Airport, fly to John Wayne Airport Orange County

    1. Take the train from San Luis Obispo to San Josetrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to John Wayne Airport Orange County (SNA)plane plane SJC - SNA
    7h 55m
    $290–977

San Luis Obispo to Santa Ana by bus and foot

Calendar4Weekly Services
Duration6h 25mAverage Duration
Ticket$42Cheapest Price
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Questions & Answers

Map of how to get from San Luis Obispo to Santa Ana.ExpandLaunch map view
  • Distance: 222.9 mi
  • Duration: 6h 25m

What companies run services between San Luis Obispo, CA, USA and Santa Ana, CA, USA?

You can take a bus from San Luis Obispo Railroad Museum to Santa Ana via Los Angeles Union Station and Los Angeles in around 6h 25m. Alternatively, Amtrak operates a train from San Luis Obispo to Santa Ana 3 times a day. Tickets cost $80–170 and the journey takes 6h 48m.

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