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How to get fromSan Luis Obispo to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus

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There are 6 ways to get from San Luis Obispo to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from San Luis Obispo County Regional Airport

    best
    1. Fly from San Luis Obispo County Regional Airport (SBP) to Lambert–St. Louis International Airport (STL)plane plane SBP - STL
    7h 40m
    $154–654

  2. Bus

    1. Take the bus from San Luis Obispo Railroad Museum to Los Angeles Union Stationbus bus FlixBus 2005
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus Greyhound US1210
    45h 30m
    $310–600

  3. Train via Kansas City (Amtrak)

    1. Take the train from San Luis Obispo to Los Angelestrain train
    2. Take the train from Los Angeles to Kansas Citytrain train
    3. Take the train from Kansas City to St. Louistrain train
    2d
    $712–1,536

  4. Drive 1,944.5 mi

    1. Drive from San Luis Obispo to St. Louiscar car 1,944.5 mi
    31h 33m
    $355–513

  5. Bus to Santa Barbara Municipal Airport, fly

    1. Take the bus from San Luis Obispo to Uc Santa Barbara Amtrak Bus Stopbus bus
    2. Fly from Santa Barbara Municipal Airport (SBA) to Lambert–St. Louis International Airport (STL)plane plane SBA - STL
    9h 48m
    $179–654

  6. Train (Amtrak)

    1. Take the train from San Luis Obispo to Los Angelestrain train Pacific Surfliner / ...
    2. Take the train from Los Angeles to St. Louistrain train Texas Eagle
    2d 14h
    $822–1,746

San Luis Obispo to St. Louis by bus

Calendar4Weekly Buses
Duration45h 30mAverage Duration
Ticket$310Cheapest Price
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Questions & Answers

Map of how to get from San Luis Obispo to St. Louis.ExpandLaunch map view
  • Distance: 1,699.8 mi
  • Duration: 7h 40m

What companies run services between San Luis Obispo, CA, USA and St. Louis, MO, USA?

United Airlines, American Airlines, and two other airlines fly from San Luis Obispo County Regional Airport (SBP) to Lambert–St. Louis International Airport (STL) 4 times a day. Alternatively, you can take a bus from San Luis Obispo Railroad Museum to St Louis Bus Station via Los Angeles Union Station in around 45h 30m.

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