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How to get fromSan Marco to Key Westby plane, bus, shuttle, train, car, or bus (Flixbus, Greyhound)

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There are 6 ways to get from San Marco to Key West by plane, bus, shuttle, train, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Jacksonville

    best
    1. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    5h 49m
    $373–816

  2. Drive to Orlando Sanford, fly

    cheapest
    1. Drive from San Marco to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    3h 39m
    $68–285

  3. Bus, shuttle

    1. Take the bus from Jacksonville to Miami Golden Gladesbus bus FlixBus 2431
    2. Take a shuttle bus from Bayside Marketplace to Plaza Hotelshuttle bus
    16h 58m
    $122–165

  4. Train, bus

    1. Take the train from Jacksonville to Hollywood Amtrak Stationtrain train
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    18h 2m
    $157–323

  5. Drive 501.6 mi

    1. Drive from San Marco to Key Westcar car 501.6 mi
    9h 5m
    $92–133

  6. Bus

    1. Take the bus from Jacksonville to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    17h
    $84–167

San Marco to Key West by bus, train, and foot

Calendar14Weekly Services
Duration18h 2mAverage Duration
Ticket$157Cheapest Price
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Questions & Answers

Map of how to get from San Marco to Key West.ExpandLaunch map view
  • Distance: 429.3 mi
  • Duration: 5h 49m

What companies run services between San Marco, FL, USA and Key West, FL, USA?

American Airlines and Delta fly from Jacksonville (JAX) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from San Marco Blvd + Nira St to N Roosevelt & 3rd Street via JRTC Bay Q, Jacksonville, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 17h.

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