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How to get fromSan Mateo to Santa Anaby plane, train, bus, train (Amtrak), car, tram, or subway

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There are 7 ways to get from San Mateo to Santa Ana by plane, train, bus, train (Amtrak), car, tram, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from San Francisco International Airport

    best
    1. Fly from San Francisco International Airport (SFO) to John Wayne Airport Orange County (SNA)plane plane SFO - SNA
    3h 6m
    $151–750

  2. Bus

    cheapest
    1. Take the bus from San Jose, CA - Huong Lan Sandwich to Westminster, CA - ABC Supermarketbus bus San Jose
    11h 23m
    $51–70

  3. Caltrain, bus

    1. Take the train from San Mateo Caltrain Southbound to San Jose Diridon Caltrain Southboundtrain train Local Weekday / ...
    2. Take the bus from San Jose Diridon Station to Santa Ana Bus Stopbus bus Greyhound US0831
    11h 14m
    $62–119

  4. Caltrain, train

    1. Take the train from San Mateo Caltrain Southbound to San Jose Diridon Caltrain Southboundtrain train
    2. Take the train from San Jose to Los Angelestrain train
    3. Take the train from Los Angeles to Santa Anatrain train
    14h 19m
    $147–312

  5. Drive 400.5 mi

    1. Drive from San Mateo to Santa Anacar car 400.5 mi
    6h 46m
    $74–106

  6. Caltrain to Norman Y. Mineta San José International Airport, fly

    1. Take the train from San Mateo Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to John Wayne Airport Orange County (SNA)plane plane SJC - SNA
    3h 37m
    $229–846

  7. Caltrain, tram, BART to Oakland International Airport, fly

    1. Take the train from San Mateo Caltrain Northbound to San Francisco Caltrain Northboundtrain train
    2. Take the tram from King St & 4th St to Metro Embarcadero Stationtram tram
    3. Take the subway from Embarcadero to Coliseumsubway subway
    4. Fly from Oakland International Airport (OAK) to John Wayne Airport Orange County (SNA)plane plane OAK - SNA
    4h 5m
    $252–802

San Mateo to Santa Ana by train and bus

Calendar7Weekly Services
Duration11h 14mAverage Duration
Ticket$62Cheapest Price
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Questions & Answers

Map of how to get from San Mateo to Santa Ana.ExpandLaunch map view
  • Distance: 384.1 mi
  • Duration: 3h 6m

What companies run services between San Mateo, CA, USA and Santa Ana, CA, USA?

Frontier Airlines, Alaska Airlines, Inc., and two other airlines fly from San Francisco International Airport (SFO) to John Wayne Airport Orange County (SNA) hourly. Alternatively, you can take a train from San Mateo Caltrain Southbound to Santa Ana via San Jose Diridon Caltrain Southbound, San Jose, and Los Angeles in around 14h 19m.

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