There are 7 ways to get from San Sebastián de los Reyes to Palermo by plane, train, bus, ferry, or car ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Palermo Airport
best- Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Palermo Airport (PMO)plane MAD - PMO
5h 35m€55–189Train, bus
- Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Marseille St Charlestrain
- Take the bus from Marseille, Gare de Marseille-Saint-Charles to Savonabus 404
- Take the train from Savona to Genova P.Za Principetrain Ic
- Take the train from Genova P.Za Principe to Roma Terminitrain Fb / ...
- Take the train from Roma Termini to Palermo Centraletrain Ic
34h 55m€315–636Train, ferry, car ferry
- Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Santstrain Ave
- Take the ferry from Port de Barcelona to Port of Genoaferry
- Take the carferry from Port of Genoa to Port of Palermocarferry
40h 14m€248–472Bus
- Take the bus from Madrid to Milanbus FlixBus N1138
- Take the bus from Milano, Autostazione Lampugnano to Palermobus N597
2d€275–477Fly to Trapani Airport, bus
- Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Trapani Airport (TPS)plane MAD - TPS
- Take the bus from Trapani Birgi Airport to Palermo Via Belgio/Via dei Nebrodibus
9h 2m€68–252Train, car ferry
- Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Santstrain Ave
- Take the carferry from Port de Barcelona to Port of Genoacarferry
- Take the carferry from Port of Genoa to Port of Palermocarferry
47h 53m€245–469Bus, train
- Take the bus from Méndez Álvaro Estación Sur to Padovabus
- Take the train from Padova to Verona Porta Nuovatrain Fr
- Take the bus from Verona Porta Nuova Station to Palermo Piazza Cairolibus
2d 7h
San Sebastián de los Reyes to Palermo by train and bus
Questions & Answers
The cheapest way to get from San Sebastián de los Reyes to Palermo is to fly which costs €50 - €190 and takes 5h 35m.
The fastest way to get from San Sebastián de los Reyes to Palermo is to fly which takes 5h 35m and costs €50 - €190.
No, there is no direct bus from San Sebastián de los Reyes to Palermo. However, there are services departing from Pºeuropa-Av.Montes De Oca and arriving at Palermo via Avenida De Asturias - Plaza De Castilla, Cibeles - Ayuntamiento, Madrid and Milano, Autostazione Lampugnano. The journey, including transfers, takes approximately 2 days 0h.
The distance between San Sebastián de los Reyes and Palermo is 1498 km.
The best way to get from San Sebastián de los Reyes to Palermo without a car is to train and bus which takes 34h 55m and costs €310 - €650.
It takes approximately 5h 35m to get from San Sebastián de los Reyes to Palermo, including transfers.
San Sebastián de los Reyes to Palermo bus services, operated by FlixBus, depart from Madrid station.
The best way to get from San Sebastián de los Reyes to Palermo is to fly which takes 5h 35m and costs €50 - €190. Alternatively, you can bus, which costs €270 - €480 and takes 2 days 0h.
San Sebastián de los Reyes to Palermo bus services, operated by FlixBus, arrive at Milan station.
There are 6403+ hotels available in Palermo.
What companies run services between San Sebastián de los Reyes, Spain and Palermo, Italy?
Ryanair, Iberia, and Vueling Airlines fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Palermo Airport (PMO) twice daily. Alternatively, you can take a bus from Pºeuropa-Av.Montes De Oca to Palermo via Intercambiador De Plaza Castilla, Avenida De Asturias - Plaza De Castilla, Cibeles, Cibeles - Ayuntamiento, Estación Sur, Madrid, and Milano, Autostazione Lampugnano in around 2d.
- Website
- ryanair.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Palermo Airport
- Ave. Duration
- 2h 30m
- When
- Wednesday to Thursday
- Estimated price
- €55–160
Flights from Adolfo Suárez Madrid–Barajas Airport to Trapani Airport via Milan Bergamo
- Ave. Duration
- 5h 30m
- When
- Sunday and Monday
- Estimated price
- €70–250
Flights from Adolfo Suárez Madrid–Barajas Airport to Trapani Airport via Pisa
- Ave. Duration
- 4h 50m
- When
- Monday, Friday, Saturday, and Sunday
- Estimated price
- €65–250
Flights from Adolfo Suárez Madrid–Barajas Airport to Trapani Airport via Rome
- Ave. Duration
- 4h 45m
- When
- Thursday, Tuesday, and Sunday
- Estimated price
- €60–280
Flights from Adolfo Suárez Madrid–Barajas Airport to Trapani Airport via Bologna
- Ave. Duration
- 6h 55m
- When
- Monday to Friday
- Estimated price
- €65–250
- Website
- iberia.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Palermo Airport
- Ave. Duration
- 2h 30m
- When
- Monday, Thursday, and Saturday
- Estimated price
- €120–800
Flights from Adolfo Suárez Madrid–Barajas Airport to Palermo Airport via Barcelona
- Ave. Duration
- 4h 22m
- When
- Wednesday, Friday, Monday, and Tuesday
- Estimated price
- €45–180
- Website
- vueling.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Palermo Airport
- Ave. Duration
- 2h 30m
- When
- Monday, Thursday, and Saturday
- Estimated price
- €120–800
Flights from Adolfo Suárez Madrid–Barajas Airport to Palermo Airport via Barcelona
- Ave. Duration
- 4h 22m
- When
- Wednesday, Friday, Monday, and Tuesday
- Estimated price
- €45–180
Rome2Rio's guide to Renfe Viajeros
Contact DetailsContact Details
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Madrid-Puerta de Atocha-Almudena Grandes to Marseille St Charles
- Ave. Duration
- 8h 42m
- Frequency
- Twice daily
- Estimated price
- €140–230
- Website
- https://www.renfe.com/es/en
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 29m
- Frequency
- 4 times a day
- Estimated price
- €75–120
- Website
- https://www.renfe.com/es/en
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 29m
- Frequency
- 4 times a day
- Estimated price
- €75–120
- Website
- https://www.renfe.com/es/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Savona to Genova P.Za Principe
- Ave. Duration
- 32 min
- Frequency
- Hourly
- Estimated price
- €4–10
- Website
- https://www.trenitalia.com/en.html
Train from Genova P.Za Principe to Roma Termini
- Ave. Duration
- 5h 40m
- Frequency
- Every 4 hours
- Estimated price
- €50–110
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Palermo Centrale
- Ave. Duration
- 11h 38m
- Frequency
- Twice daily
- Estimated price
- €90–190
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Savona to Genova P.Za Principe
- Ave. Duration
- 57 min
- Frequency
- Every 20 minutes
- Estimated price
- €5–9
- Website
- https://www.trenitalia.com/en.html
Train from Padova to Verona Porta Nuova
- Ave. Duration
- 1h 54m
- Frequency
- Every 30 minutes
- Estimated price
- €10–17
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Genova P.Za Principe to Roma Termini
- Ave. Duration
- 4h 56m
- Frequency
- Hourly
- Estimated price
- €70–150
- Schedules at
- trenitalia.com
Train from Padova to Verona Porta Nuova
- Ave. Duration
- 44 min
- Frequency
- Every 30 minutes
- Estimated price
- €12–24
- Schedules at
- trenitalia.com
Rome2Rio's guide to Renfe AVE
Contact DetailsContact Details
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 22m
- Frequency
- Every 30 minutes
- Estimated price
- €95–170
- Website
- https://www.renfe.com/es/en
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 22m
- Frequency
- Every 30 minutes
- Estimated price
- €95–170
- Website
- https://www.renfe.com/es/en
- Phone
- +34 900 926 851
- [email protected]
- Website
- iryo.eu
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 31m
- Frequency
- Hourly
- Estimated price
- €60–130
- Website
- https://iryo.eu/en/home
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 31m
- Frequency
- Hourly
- Estimated price
- €60–130
- Website
- https://iryo.eu/en/home
- Phone
- +34 900 759 781
- Website
- ouigo.com
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 23m
- Frequency
- Every 2 hours
- Estimated price
- €55–100
- Website
- https://www.ouigo.com/es/en
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 23m
- Frequency
- Every 2 hours
- Estimated price
- €55–100
- Website
- https://www.ouigo.com/es/en
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Padova to Verona Porta Nuova
- Ave. Duration
- 44 min
- Frequency
- Hourly
- Estimated price
- €10–21
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- [email protected]
- Website
- trenitalia.com
Train from Padova to Verona Porta Nuova
- Ave. Duration
- 44 min
- Frequency
- 4 times a day
- Estimated price
- €25–70
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €45–70
- 2nd Class
- €25–35
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- https://www.flixbus.fr
Bus from Marseille, Gare de Marseille-Saint-Charles to Savona
- Ave. Duration
- 4h 55m
- Frequency
- Twice daily
- Estimated price
- €29–50
- Website
- https://www.flixbus.co.uk
Bus from Madrid to Milan
- Ave. Duration
- 23h 5m
- Frequency
- Once daily
- Estimated price
- €140–240
- Website
- https://www.flixbus.co.uk
Bus from Milano, Autostazione Lampugnano to Palermo
- Ave. Duration
- 21h 55m
- Frequency
- Once daily
- Estimated price
- €130–230
- Website
- https://www.flixbus.co.uk
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Trapani Birgi Airport to Palermo Via Belgio/Via dei Nebrodi
- Ave. Duration
- 1h 25m
- Frequency
- 6 times a week
- Estimated price
- €6–10
- Schedules at
- autoservizisalemi.it
- Phone
- +4-0263-21.55.00
- Website
- tabitatour.ro
Bus from Méndez Álvaro Estación Sur to Padova
- Ave. Duration
- 27h 34m
- Frequency
- Once a week
- Estimated price
- €120–160
- Schedules at
- tabitatour.ro
- Phone
- +39 0362 185 0590
- [email protected]
- Website
- onebus.it
Bus from Verona Porta Nuova Station to Palermo Piazza Cairoli
- Ave. Duration
- 23h 57m
- Frequency
- Once a week
- Website
- https://onebus.it/
- Phone
- +39 010 209 4591
- [email protected]
- Website
- gnv.it
Ferry from Port de Barcelona to Port of Genoa
- Ave. Duration
- 13h 5m
- Frequency
- 3 times a week
- Estimated price
- €85–130
- Website
- https://www.gnv.it/en
Car ferry from Port of Genoa to Port of Palermo
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €100–160
- Website
- https://www.gnv.it/en
Car ferry from Port de Barcelona to Port of Genoa
- Ave. Duration
- 20h 45m
- Frequency
- Twice a week
- Estimated price
- €85–130
- Website
- https://www.gnv.it/en
Car ferry from Port of Genoa to Port of Palermo
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €100–160
- Website
- https://www.gnv.it/en
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
5 delightfully under-the-radar French towns you need to visit
Read the travel guide
Train travel in Spain: A guide to Renfe
Read the travel guide












































