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How to get fromSan Sebastián de los Reyes to Palermoby plane, train (Renfe, Ouigo, Trenitalia), train, ferry, car ferry, or bus

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There are 8 ways to get from San Sebastián de los Reyes to Palermo by plane, train (Renfe, Ouigo, Trenitalia), train, ferry, car ferry, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Palermo Airport

    best
    1. Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Palermo Airport (PMO)plane plane MAD - PMO
    5h 36m
    €55–227

  2. Train

    1. Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Santstrain train Ave
    2. Take the train from Barcelona-Sants to Lyon Part Dieutrain train
    3. Take the train from Lyon Part Dieu to Milano Centraletrain train Fr
    4. Take the train from Milano Centrale to Roma Terminitrain train
    5. Take the train from Roma Termini to Palermo Centraletrain train Ic
    31h 23m
    €332–628

  3. Train, ferry, car ferry

    1. Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Santstrain train Ave
    2. Take the ferry from Port de Barcelona to Port of Genoaferry ferry
    3. Take the carferry from Port of Genoa to Port of Palermocarferry car ferry
    38h 38m
    €228–429

  4. Bus

    1. Take the bus from Madrid to Milanbus bus FlixBus N1138
    2. Take the bus from Milano, Autostazione Lampugnano to Palermobus bus N597
    2d
    €285–437

  5. Fly to Trapani Airport, bus

    1. Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Trapani Airport (TPS)plane plane MAD - TPS
    2. Take the bus from Trapani Birgi Airport to Palermo Via Belgio/Via dei Nebrodibus bus
    9h 17m
    €108–492

  6. Fly to Catania–Fontanarossa Airport, bus

    1. Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Catania–Fontanarossa Airport (CTA)plane plane MAD - CTA
    2. Take the bus from Catania Fontanarossa Airport Bus Stop to Palermo Via Tommaso Fazellobus bus
    8h 27m
    €63–230

  7. Train, car ferry

    1. Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Santstrain train Ave
    2. Take the carferry from Port de Barcelona to Port of Genoacarferry car ferry
    3. Take the carferry from Port of Genoa to Port of Palermocarferry car ferry
    46h 16m
    €225–426

  8. Bus, train

    1. Take the bus from Méndez Álvaro Estación Sur to Padovabus bus
    2. Take the train from Vicenza to Verona Porta Nuovatrain train Fr
    3. Take the bus from Verona Porta Nuova Station to Palermo Piazza Cairolibus bus
    2d 8h
    €333–520

San Sebastián de los Reyes to Palermo by bus

Calendar7Weekly Buses
Duration2dAverage Duration
Ticket€285Cheapest Price
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Comparing Your Travel Options

Map of how to get from San Sebastián de los Reyes to Palermo.ExpandLaunch map view
  • Distance: 1,497.8 km
  • Duration: 5h 36m

What companies run services between San Sebastián de los Reyes, Spain and Palermo, Italy?

Ryanair, Iberia, and Vueling Airlines fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Palermo Airport (PMO) once daily. Alternatively, you can take a train from Alcobendas-San Sebastián de los Reyes to Palermo Centrale via Madrid-Atocha Cercanías, Madrid-Puerta de Atocha-Almudena Grandes, Barcelona-Sants, Lyon Part Dieu, Milano Centrale, and Roma Termini in around 31h 23m.

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