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How to get fromSan Ysidro to San Luis Obispoby tram, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

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There are 6 ways to get from San Ysidro to San Luis Obispo by tram, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Tram, fly to San Luis Obispo County Regional Airport

    best
    1. Take the tram from Beyer Blvd Station to America Plaza Stationtram tram
    2. Fly from San Diego International Airport (SAN) to San Luis Obispo County Regional Airport (SBP)plane plane SAN - SBP
    4h 31m
    $176–372

  2. Bus

    cheapest
    1. Take the bus from San Ysidro Bus Terminal to Los Angeles Union Stationbus bus Greyhound US0831
    2. Take the bus from Los Angeles Union Station to San Luis Obispo Railroad Museumbus bus FlixBus 2005
    9h 20m
    $54–95

  3. Train (Amtrak)

    1. Take the train from San Diego to San Luis Obispotrain train Pacific Surfliner
    10h 17m
    $112–245

  4. Drive 318.8 mi

    1. Drive from San Ysidro to San Luis Obispocar car 318.8 mi
    5h 46m
    $59–84

  5. Fly to Santa Barbara Municipal Airport, bus

    1. Fly from San Diego International Airport (SAN) to Santa Barbara Municipal Airport (SBA)plane plane SAN - SBA
    2. Take the bus from Uc Santa Barbara Amtrak Bus Stop to San Luis Obispobus bus
    6h 46m
    $196–292

  6. Bus via Santa Maria Airport (SMX)

    1. Take the bus from San Diego to LAX Terminal 3 Shared Rides Stopbus bus
    2. Take the bus from Los Angeles Airport, CA to Santa Maria Airport, CAbus bus
    3. Take the bus from Santa Maria Transit Center to Government Centerbus bus 10N
    12h 27m
    $147–220

San Ysidro to San Luis Obispo by bus

Calendar8Weekly Buses
Duration9h 20mAverage Duration
Ticket$54Cheapest Price
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Questions & Answers

Map of how to get from San Ysidro to San Luis Obispo.ExpandLaunch map view
  • Distance: 284 mi
  • Duration: 4h 31m

What companies run services between San Ysidro, CA, USA and San Luis Obispo, CA, USA?

You can take a bus from San Ysidro Bl & I-805 to San Luis Obispo Railroad Museum via San Ysidro Bus Terminal and Los Angeles Union Station in around 9h 20m. Alternatively, Amtrak operates a train from San Diego to San Luis Obispo twice daily. Tickets cost $110–230 and the journey takes 8h 36m.

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