There are 7 ways to get from Sanford to Chicago by train, plane, bus (Flixbus, Greyhound), train (Amtrak), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train to Orlando, fly to Chicago Midway International Airport
best- Take the train from Sanford to Sand Lake Roadtrain
- Fly from Orlando (MCO) to Chicago Midway International Airport (MDW)plane MCO - MDW
5h 51m$207–501Train to Orlando, fly to Chicago O'Hare International Airport
cheapest- Take the train from Sanford to Sand Lake Roadtrain
- Fly from Orlando (MCO) to Chicago O'Hare International Airport (ORD)plane MCO - ORD
6h 14m$77–611Bus
- Take the bus from Orlando Bus Station to Atlanta Bus Stationbus FlixBus N2401 / ...
- Take the bus from Atlanta Bus Station to Chicago Bus Stationbus Greyhound US0100
26h 29m$170–346Train (Amtrak)
- Take the train from Deland to Chicago Union Stationtrain Floridian
39h 16m$503–1,103Drive 1,103.3 mi
- Drive from Sanford to Chicagocar 1,103.3 mi
20h 4m$202–291Fly Orlando Sanford to South Bend, train
- Fly from Orlando Sanford (SFB) to South Bend (SBN)plane SFB - SBN
- Take the train from South Bend Airport to Van Buren St.train
5h 27m$150–661Train to Orlando, fly to General Mitchell International Airport, train
- Take the train from Sanford to Sand Lake Roadtrain
- Fly from Orlando (MCO) to General Mitchell International Airport (MKE)plane MCO - MKE
- Take the train from Milwaukee to Chicago Union Stationtrain
8h 15m$324–1,180
Sanford to Chicago by train and bus
Questions & Answers
The cheapest way to get from Sanford to Chicago is to bus which costs $170 - $350 and takes 26h 29m.
The fastest way to get from Sanford to Chicago is to fly and train which takes 5h 27m and costs $150 - $700.
No, there is no direct bus from Sanford to Chicago station. However, there are services departing from N Garland Ave & W Amelia St and arriving at Chicago Bus Station via Orlando Bus Station and Atlanta Bus Station. The journey, including transfers, takes approximately 26h 29m.
No, there is no direct train from Sanford to Chicago station. However, there are services departing from Sanford and arriving at Chicago Union Station via Deland. The journey, including transfers, takes approximately 39h 16m.
The distance between Sanford and Chicago is 1053 miles. The road distance is 1109.8 miles.
The best way to get from Sanford to Chicago without a car is to bus which takes 26h 29m and costs $170 - $350.
It takes approximately 5h 51m to get from Sanford to Chicago, including transfers.
Sanford to Chicago bus services, operated by Flixbus USA, depart from Orlando Bus Station.
Sanford to Chicago train services, operated by Amtrak, depart from Deland station.
The best way to get from Sanford to Chicago is to bus which takes 26h 29m and costs $170 - $350. Alternatively, you can train, which costs $500 - $1,100 and takes 39h 16m.
What companies run services between Sanford, FL, USA and Chicago, IL, USA?
You can take a train from Sanford to Chicago Bus Station via LYNX Central, N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, and Atlanta Bus Station in around 26h 29m. Alternatively, Amtrak operates a train from Deland to Chicago Union Station once daily. Tickets cost $500–1,100 and the journey takes 37h 56m.
- Website
- southwest.com
Flights from Orlando to Chicago Midway International Airport
- Ave. Duration
- 2h 46m
- When
- Every day
- Estimated price
- $80–390
Flights from Orlando to Chicago Midway International Airport via Nashville
- Ave. Duration
- 4h 38m
- When
- Tuesday to Friday
- Estimated price
- $85–400
Flights from Orlando to General Mitchell International Airport
- Ave. Duration
- 2h 51m
- When
- Every day
- Estimated price
- $130–600
Flights from Orlando to General Mitchell International Airport via Nashville
- Ave. Duration
- 4h 30m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $130–600
Flights from Orlando to General Mitchell International Airport via Chicago Midway International Airport
- Ave. Duration
- 4h 33m
- When
- Tuesday, Wednesday, Saturday, and Sunday
- Estimated price
- $130–600
- Website
- aa.com
Flights from Orlando to Chicago O'Hare International Airport
- Ave. Duration
- 3h 16m
- When
- Every day
- Estimated price
- $70–340
Flights from Orlando to General Mitchell International Airport via Charlotte
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $130–650
- Website
- united.com
Flights from Orlando to Chicago O'Hare International Airport
- Ave. Duration
- 3h 7m
- When
- Every day
- Estimated price
- $70–340
- Website
- delta.com
Flights from Orlando to Chicago O'Hare International Airport via Atlanta
- Ave. Duration
- 5h 4m
- When
- Every day
- Estimated price
- $70–340
Flights from Orlando to General Mitchell International Airport via Atlanta
- Ave. Duration
- 4h 38m
- When
- Every day
- Estimated price
- $130–600
- Website
- allegiantair.com
Flights from Orlando Sanford to South Bend
- Ave. Duration
- 2h 29m
- When
- Thursday, Sunday, Monday, and Friday
- Estimated price
- $130–650
- Website
- flyfrontier.com
Flights from Orlando to Chicago O'Hare International Airport
- Ave. Duration
- 3h 20m
- When
- Every day
- Estimated price
- $70–350
Flights from Orlando to General Mitchell International Airport
- Ave. Duration
- 2h 58m
- When
- Tuesday, Thursday, and Sunday
- Estimated price
- $160–550
- Phone
- +1 855-724-5411
- [email protected]
- Website
- SunRail
Train from Sanford to Sand Lake Road
- Ave. Duration
- 57 min
- Frequency
- Hourly
- Estimated price
- $3–5
- Website
- SunRail
Train from Sanford to Sand Lake Road
- Ave. Duration
- 57 min
- Frequency
- Hourly
- Estimated price
- $3–5
- Website
- SunRail
Train from Sanford to Sand Lake Road
- Ave. Duration
- 57 min
- Frequency
- Hourly
- Estimated price
- $3–5
- Website
- SunRail
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Deland to Chicago Union Station
- Ave. Duration
- 37h 56m
- Frequency
- Once daily
- Estimated price
- $500–1,100
- Website
- Amtrak
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $27–60
- Website
- Amtrak
- Phone
- +1 219-926-5744
- Website
- mysouthshoreline.com
Train from South Bend Airport to Van Buren St.
- Ave. Duration
- 2h 1m
- Frequency
- Every 2 hours
- Estimated price
- $13–15
- Schedules at
- mysouthshoreline.com
- Adults 14-64
- $13–15
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Orlando Bus Station to Atlanta Bus Station
- Ave. Duration
- 7h 15m
- Frequency
- Every 2 hours
- Estimated price
- $65–120
- Schedules at
- Flixbus USA
Bus from Atlanta Bus Station to Chicago Bus Station
- Ave. Duration
- 16h 10m
- Frequency
- 3 times a day
- Estimated price
- $110–190
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Orlando Bus Station to Atlanta Bus Station
- Ave. Duration
- 10h 10m
- Frequency
- Twice daily
- Estimated price
- $65–130
- Website
- Greyhound
Bus from Atlanta Bus Station to Chicago Bus Station
- Ave. Duration
- 16h
- Frequency
- Every 4 hours
- Estimated price
- $100–210
- Website
- Greyhound
Want to know more about travelling around United States
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More Questions & Answers
Sanford to Chicago bus services, operated by Flixbus USA, arrive at Atlanta Bus Station.
Chicago is 1h behind Sanford. It is currently 8:49 AM in Sanford and 7:49 AM in Chicago.
Sanford to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Sanford to Chicago is 1110 miles. It takes approximately 20h 4m to drive from Sanford to Chicago.
There are 1082+ hotels available in Chicago.






