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How to get fromSanford to Florida Keysby plane, bus, train, shuttle, or car

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There are 7 ways to get from Sanford to Florida Keys by plane, bus, train, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando Sanford to Key West International Airport, bus

    best
    1. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    2. Take the bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodgebus bus
    4h 11m
    $116–341

  2. Train, bus

    cheapest
    1. Take the train from Sanford to Sand Lake Roadtrain train
    2. Take the bus from Orlando to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    12h 48m
    $61–110

  3. Train, bus, shuttle

    1. Take the train from Sanford to Sand Lake Roadtrain train
    2. Take the bus from Orlando - RedCoach Station, FL to Miami Airportbus bus
    3. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    12h 22m
    $212–310

  4. Train, bus via Pembroke Pines

    1. Take the train from Winter Park Amtrak Station to Hollywood Amtrak Stationtrain train Silver Meteor / ...
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    14h 27m
    $107–223

  5. Drive 373.6 mi

    1. Drive from Sanford to Florida Keyscar car 373.6 mi
    7h 48m
    $69–99

  6. Train to Orlando, fly to Key West International Airport

    1. Take the train from Sanford to Sand Lake Roadtrain train
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    6h 31m
    $152–750

  7. Train to Orlando, fly to Miami International Airport, shuttle

    1. Take the train from Sanford to Sand Lake Roadtrain train
    2. Fly from Orlando (MCO) to Miami International Airport (MIA)plane plane MCO - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 5m
    $707–1,290

Sanford to Florida Keys by train, bus, shuttle, and foot

Calendar21Weekly Services
Duration12h 22mAverage Duration
Ticket$212Cheapest Price
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Questions & Answers

Map of how to get from Sanford to Florida Keys.ExpandLaunch map view
  • Distance: 314.6 mi
  • Duration: 4h 11m

What companies run services between Sanford, FL, USA and Florida Keys, FL, USA?

There is no direct connection from Sanford to Florida Keys. However, you can fly to Key West International Airport (EYW), walk to Key West Airport, take the shuttle to Key West, FL, walk to Whitehead & Eaton, take the bus to Sugarloaf Key - Lower - Opposite Sugarloaf Lodge, then walk to Florida Keys. Alternatively, you can take a train from Sanford to Florida Keys via Sand Lake Road, Office Ct & Sand Lake Sunrail, Mccoy Rd & Central Ave, Orlando - RedCoach Station, FL, Miami Airport, Miami, FL - International Airport, Summerland Key - Mote Marine Lab, Summerland - Opposite Mote Lab, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 12h 22m.

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