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How to get fromSanford to Indianapolisby train, plane, bus (Flixbus, Greyhound), train (Amtrak), or car

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There are 6 ways to get from Sanford to Indianapolis by train, plane, bus (Flixbus, Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Orlando, fly

    best
    1. Take the train from Sanford to Sand Lake Roadtrain train
    2. Fly from Orlando (MCO) to Indianapolis (IND)plane plane MCO - IND
    5h 51m
    $187–498

  2. Fly from Orlando Sanford

    cheapest
    1. Fly from Orlando Sanford (SFB) to Indianapolis (IND)plane plane SFB - IND
    3h 19m
    $115–574

  3. Bus

    1. Take the bus from Orlando Bus Station to Atlanta Bus Stationbus bus FlixBus N2401 / ...
    2. Take the bus from Atlanta Bus Station to Indianapolisbus bus FlixBus 2512
    22h 16m
    $155–286

  4. Train (Amtrak)

    1. Take the train from Deland to Alexandriatrain train Silver Meteor / ...
    2. Take the train from Alexandria to Indianapolistrain train Cardinal
    36h 30m
    $483–1,073

  5. Drive 922.4 mi

    1. Drive from Sanford to Indianapoliscar car 922.4 mi
    16h 57m
    $169–244

  6. Bus via Indianapolis Union Station

    1. Take the bus from Orlando Bus Station to Atlanta Bus Stationbus bus FlixBus N2401 / ...
    2. Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus bus Greyhound US0100
    22h 26m
    $150–296

Sanford to Indianapolis by train and bus

Calendar12Weekly Services
Duration22h 16mAverage Duration
Ticket$155Cheapest Price
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Questions & Answers

Map of how to get from Sanford to Indianapolis.ExpandLaunch map view
  • Distance: 889.7 mi
  • Duration: 5h 51m

What companies run services between Sanford, FL, USA and Indianapolis, IN, USA?

You can take a train from Sanford to Indianapolis via LYNX Central, N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, and Atlanta Bus Station in around 22h 16m. Alternatively, you can take a train from Sanford to Indianapolis via Deland and Alexandria in around 36h 30m.

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