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How to get fromSanford to Key Westby plane, train, bus, shuttle, car, or bus (Flixbus, Greyhound)

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There are 7 ways to get from Sanford to Key West by plane, train, bus, shuttle, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Orlando Sanford

    best
    1. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    1h 25m
    $50–260

  2. Train, bus, shuttle

    1. Take the train from Sanford to Sand Lake Roadtrain train
    2. Take the bus from Orlando - RedCoach Station, FL to Miami Airportbus bus
    3. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    12h 45m
    $232–330

  3. Train, bus via Pembroke Pines

    1. Take the train from Winter Park Amtrak Station to Hollywood Amtrak Stationtrain train
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    15h 14m
    $107–223

  4. Drive 389 mi

    1. Drive from Sanford to Key Westcar car 389 mi
    8h 11m
    $71–103

  5. Train to Orlando, fly

    1. Take the train from Sanford to Sand Lake Roadtrain train
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    3h 45m
    $86–669

  6. Train, bus

    1. Take the train from Sanford to Sand Lake Roadtrain train
    2. Take the train from Orlando to Miamitrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    13h 7m
    $87–245

  7. Bus

    1. Take the bus from Orlando to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    13h 54m
    $61–110

Sanford to Key West by train, bus, and shuttle

Calendar21Weekly Services
Duration12h 45mAverage Duration
Ticket$232Cheapest Price
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Questions & Answers

Map of how to get from Sanford to Key West.ExpandLaunch map view
  • Distance: 295.4 mi
  • Duration: 1h 25m

What companies run services between Sanford, FL, USA and Key West, FL, USA?

Allegiant Air flies from Orlando Sanford (SFB) to Key West International Airport (EYW) 3 times a week. Alternatively, you can take a train from Sanford to N Roosevelt & 3rd Street via LYNX Central, N Garland Ave & W Amelia St, Florida Mall, Orlando, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 13h 54m.

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