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How to get fromSanford to St. Louisby train, plane, bus (Flixbus, Greyhound), train (Amtrak), or car

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There are 5 ways to get from Sanford to St. Louis by train, plane, bus (Flixbus, Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Orlando, fly to Lambert–St. Louis International Airport

    best
    1. Take the train from Sanford to Sand Lake Roadtrain train
    2. Fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL)plane plane MCO - STL
    5h 33m
    $188–379

  2. Fly Orlando Sanford to Midamerica St. Louis Airport, train

    cheapest
    1. Fly from Orlando Sanford (SFB) to Midamerica St. Louis Airport (BLV)plane plane SFB - BLV
    2. Take the train from SHILOH-SCOTT station to CIVIC CENTER stationtrain train
    3h 25m
    $111–443

  3. Bus

    1. Take the bus from Orlando Bus Station to Atlanta Bus Stationbus bus FlixBus N2401 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    22h 9m
    $150–296

  4. Train (Amtrak)

    1. Take the train from Deland to Chicago Union Stationtrain train Floridian
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    45h 2m
    $588–1,293

  5. Drive 985.8 mi

    1. Drive from Sanford to St. Louiscar car 985.8 mi
    16h 45m
    $180–260

Sanford to St. Louis by train and bus

Calendar24Weekly Services
Duration22h 9mAverage Duration
Ticket$150Cheapest Price
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Questions & Answers

Map of how to get from Sanford to St. Louis.ExpandLaunch map view
  • Distance: 940.6 mi
  • Duration: 5h 33m

What companies run services between Sanford, FL, USA and St. Louis, MO, USA?

You can take a train from Sanford to St Louis Bus Station via LYNX Central, N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, and Atlanta Bus Station in around 22h 9m. Alternatively, you can take a train from Sanford to St. Louis via Deland and Chicago Union Station in around 45h 2m.

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