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How to get fromSanford to Hyannisby bus (Greyhound), train, bus, train (Amtrak), car, or plane

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There are 7 ways to get from Sanford to Hyannis by bus (Greyhound), train, bus, train (Amtrak), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Wells Transportation Center to Bostonbus bus Greyhound US0265s
    2. Take the bus from Boston South Buses to Hyannis Transportation Centerbus bus Hyannis - South Shore to Logan Airport
    4h 49m
    $81–109

  2. Drive 155.3 mi

    cheapest
    1. Drive from Sanford to Hyanniscar car 155.3 mi
    3h 11m
    $29–41

  3. Train, bus

    1. Take the train from Wells to Bostontrain train Downeaster
    2. Take the bus from Boston South Station to Hyannis Transportation Centerbus bus Boston
    5h 2m
    $87–149

  4. Train

    1. Take the train from Wells to Bostontrain train Downeaster
    2. Take the train from South Station to Hyannistrain train CapeFLYER
    5h 59m
    $77–131

  5. Train, bus via Woburn

    1. Take the train from Wells to Woburn Amtrak Stationtrain train Downeaster
    2. Take the bus from Logan International Airport to Hyannis Transportation Centerbus bus Hyannis - South Shore to Logan Airport
    5h 39m
    $102–150

  6. Train, bus via Woburn #2

    1. Take the train from Wells to Woburn Amtrak Stationtrain train Downeaster
    2. Take the bus from Boston to Hyannisbus bus Bz 0956 / ...
    5h 49m
    $90–155

  7. Train, fly

    1. Take the train from Wells to Woburn Amtrak Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Barnstable Municipal Airport (HYA)plane plane BOS - HYA
    4h 27m
    $194–420

Boston Logan Airport (BOS) to Barnstable Municipal Airport (HYA) flights

Calendar34Weekly Planes
Duration1h 10mAverage Duration
Ticket$122Cheapest Price
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Questions & Answers

Map of how to get from Sanford to Hyannis.ExpandLaunch map view
  • Distance: 164.8 mi
  • Duration: 4h 49m

What companies run services between Sanford, ME, USA and Hyannis, MA, USA?

You can take a vehicle from Sanford to Hyannis Transportation Center via Wells Transportation Center, Boston, and Boston South Buses in around 4h 49m. Alternatively, you can take a vehicle from Sanford to Hyannis via Wells, Boston, North Station, Downtown Crossing, and South Station in around 5h 59m.

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