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How to get fromSanford to Niagara Fallsby taxi, plane, bus, bus (Greyhound), train (Amtrak), car, train, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Sanford to Niagara Falls by taxi, plane, bus, bus (Greyhound), train (Amtrak), car, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Portland, fly, bus

    best
    1. Take the taxi from Sanford to Portland-Airport-PWMtaxi taxi
    2. Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)plane plane PWM - BUF
    3. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    6h 21m
    $230–834

  2. Drive 488.8 mi

    cheapest
    1. Drive from Sanford to Niagara Fallscar car 488.8 mi
    9h 55m
    $90–129

  3. Bus (Greyhound)

    1. Take the bus from Wells Transportation Center to Bostonbus bus Greyhound US0265s
    2. Take the bus from Boston to Buffalobus bus Greyhound US0171
    14h 45m
    $126–216

  4. Train

    1. Take the train from Wells to Bostontrain train
    2. Take the train from Boston to Buffalo Depew Stationtrain train
    3. Take the train from Buffalo Depew Station to Niagara Falls Amtrak Stationtrain train
    16h 57m
    $231–579

  5. Drive to Manchester Airport, fly, bus

    1. Drive from Sanford to Manchester-Airport-MHTcar car
    2. Fly from Manchester Airport (MHT) to Buffalo Niagara International Airport (BUF)plane plane MHT - BUF
    3. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    7h 16m
    $134–723

  6. Train to Boston Logan Airport, fly, bus

    1. Take the train from Wells to Woburn Amtrak Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    3. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    7h 9m
    $158–668

  7. Bus via Ithaca

    1. Take the bus from Wells Transportation Center to Bostonbus bus
    2. Take the bus from Boston to Ithacabus bus
    3. Take the bus from Ithaca to Niagara Falls USAbus bus
    16h 25m
    $137–224

Portland (PWM) to Buffalo Niagara International Airport (BUF) flights

Calendar110Weekly Planes
Duration4h 55mAverage Duration
Ticket$122Cheapest Price
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Questions & Answers

Map of how to get from Sanford to Niagara Falls.ExpandLaunch map view
  • Distance: 488.9 mi
  • Duration: 6h 21m

What companies run services between Sanford, ME, USA and Niagara Falls, NY, USA?

You can take a vehicle from Sanford to Main Street & Pine Avenue via Wells Transportation Center, Boston, Buffalo, and Ellicott Street & MTC Static in around 14h 45m. Alternatively, you can take a vehicle from Sanford to Niagara Falls Amtrak Station via Wells, Boston, North Station, Back Bay, Boston, and Buffalo Depew Station in around 16h 57m.

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