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How to get fromSanibel Island to Charlestonby plane, bus, train, or car

Find Transport to Charleston

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There are 4 ways to get from Sanibel Island to Charleston by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Ft. Myers (RSW) to Charleston International Airport (CHS)plane plane RSW - CHS
    3h 44m
    $178–642

  2. Drive 547.1 mi

    cheapest
    1. Drive from Sanibel Island to Charlestoncar car 547.1 mi
    10h 4m
    $100–145

  3. Bus, train via Orlando (Amtrak)

    1. Take the bus from Fort Myers Amtrak Bus Stop to Orlandobus bus Amtrak Thruway Connecting Service
    2. Take the train from Orlando to Charleston Amtrak Stationtrain train Silver Meteor
    17h 5m
    $272–460

  4. Bus, train

    1. Take the bus from Fort Myers Bus Stop to Hollywood Sheridan Trirail Stationbus bus FlixBus 2421
    2. Take the train from Fort Lauderdale Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor
    17h 58m
    $311–573

Ft. Myers (RSW) to Charleston International Airport (CHS) flights

Calendar11Weekly Planes
Duration2h 20mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Sanibel Island to Charleston.ExpandLaunch map view
  • Distance: 489.3 mi
  • Duration: 3h 44m

What companies run services between Sanibel Island, FL, USA and Charleston, SC, USA?

Breeze Airways and Delta fly from Ft. Myers (RSW) to Charleston International Airport (CHS) twice daily.

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