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How to get fromSanibel Island to Columbiaby plane, bus, train, bus (Flixbus, Greyhound), or car

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There are 4 ways to get from Sanibel Island to Columbia by plane, bus, train, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Ft. Myers (RSW) to Columbia (CAE)plane plane RSW - CAE
    5h 40m
    $163–552

  2. Drive 597.5 mi

    cheapest
    1. Drive from Sanibel Island to Columbiacar car 597.5 mi
    10h 38m
    $109–158

  3. Bus, train

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus FlixBus 2421
    2. Take the train from Tampa to Columbia Stationtrain train Floridian
    16h 31m
    $243–457

  4. Bus

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Sumter Bus Stopbus bus
    4. Take the bus from James E Clyburn Intermodal Transportation Center to Assembly Senate Northbus bus 44
    21h 31m
    $121–216

Ft. Myers (RSW) to Columbia (CAE) flights

Calendar89Weekly Planes
Duration5h 27mAverage Duration
Ticket$86Cheapest Price
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Questions & Answers

Map of how to get from Sanibel Island to Columbia.ExpandLaunch map view
  • Distance: 546.8 mi
  • Duration: 5h 40m

What companies run services between Sanibel Island, FL, USA and Columbia, SC, USA?

Delta, American Airlines, and United Airlines fly from Ft. Myers (RSW) to Columbia (CAE) hourly. Alternatively, you can take a vehicle from Sanibel Island to Assembly Senate North via Mcgregor Blvd @ Davis Rd, South Fort Myers Transfer/P&R, Fort Myers Bus Stop, Orlando Bus Station, Jacksonville, Sumter Bus Stop, and James E Clyburn Intermodal Transportation Center in around 21h 31m.

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