What is the cheapest way to get from Sanibel Island to Florida Keys?

The cheapest way to get from Sanibel Island to Florida Keys is to drive which costs $45 - $70 and takes 5h 42m.

What is the fastest way to get from Sanibel Island to Florida Keys?

The fastest way to get from Sanibel Island to Florida Keys is to drive which takes 5h 42m and costs $45 - $70.

Is there a direct bus between Sanibel Island and Florida Keys?

No, there is no direct bus from Sanibel Island to Florida Keys. However, there are services departing from Mcgregor Blvd @ Davis Rd and arriving at Sugarloaf Key - Lower - Sugarloaf Lodge via South Fort Myers Transfer/P&R, Fort Myers Bus Stop, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 11h 50m.

Is there a direct ferry between Sanibel Island and Florida Keys?

No, there is no direct ferry from Sanibel Island to Florida Keys. However, there are services departing from Fort Myers Beach, FL and arriving at Key West, FL via . The journey, including transfers, takes approximately 6h 12m.

How far is it from Sanibel Island to Florida Keys?

The distance between Sanibel Island and Florida Keys is 166 miles. The road distance is 266.9 miles.

How do I travel from Sanibel Island to Florida Keys without a car?

The best way to get from Sanibel Island to Florida Keys without a car is to ferry which takes 6h 12m and costs $160 - $180.

How long does it take to get from Sanibel Island to Florida Keys?

It takes approximately 6h 12m to get from Sanibel Island to Florida Keys, including transfers.

Where do I catch the Sanibel Island to Florida Keys bus from?

Sanibel Island to Florida Keys bus services, operated by FlixBus-us, depart from Fort Myers Bus Stop station.

Where does the Sanibel Island to Florida Keys bus arrive?

Sanibel Island to Florida Keys bus services, operated by FlixBus-us, arrive at Miami Airport Station.

Can I drive from Sanibel Island to Florida Keys?

Yes, the driving distance between Sanibel Island to Florida Keys is 267 miles. It takes approximately 5h 42m to drive from Sanibel Island to Florida Keys.

Where can I stay near Florida Keys?

There are 981+ hotels available in Florida Keys.

Sanibel Island to Florida Keys - 3 ways to travel via ferry, bus, and car

How to get fromSanibel Island to Florida Keys

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There are 3 ways to get from Sanibel Island to Florida Keys by ferry, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Ferry
best
1. Take the ferry from Fort Myers Beach, FL to Key West, FLferry Fort Myers Beach
6h 12m
$168–179
Drive 265.4 mi
cheapest
1. Drive from Sanibel Island to Florida Keyscar 265.4 mi
5h 42m
$49–70
Bus
1. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus FlixBus 2421
2. Take the bus from Miami Airport Station to Big Pine Keybus Greyhound US0720s
11h 50m
$69–118

Questions & Answers

Map of how to get from Sanibel Island to Florida Keys.

Launch map view

Distance: 165.5 mi
Duration: 6h 12m

What companies run services between Sanibel Island, FL, USA and Florida Keys, FL, USA?

Key West Express operates a ferry from Fort Myers Beach, FL to Key West, FL once daily. Tickets cost $130 and the journey takes 4h. Alternatively, you can take a vehicle from Sanibel Island to Florida Keys via Mcgregor Blvd @ Davis Rd, South Fort Myers Transfer/P&R, Fort Myers Bus Stop, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 11h 50m.

Bus operators

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