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How to get fromSanibel Island to Jacksonvilleby bus (Flixbus), bus, train, car, or plane

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There are 7 ways to get from Sanibel Island to Jacksonville by bus (Flixbus), bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Fort Myers 7-11 to University of South Florida - 3801 USF Holly Drbus bus
    2. Take the bus from University of South Florida to Gainesvillebus bus
    3. Take the bus from Gainesville to Jacksonvillebus bus
    8h 31m
    $132–204

  2. Drive 309.3 mi

    cheapest
    1. Drive from Sanibel Island to Jacksonvillecar car 309.3 mi
    5h 57m
    $57–82

  3. Bus, train

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus FlixBus 2421
    2. Take the train from Tampa to Jacksonvilletrain train Floridian
    11h 23m
    $159–275

  4. Fly from Ft. Myers

    1. Fly from Ft. Myers (RSW) to Jacksonville (JAX)plane plane RSW - JAX
    6h 11m
    $387–893

  5. Bus via Orlando (Flixbus)

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus FlixBus 2421
    2. Take the bus from Orlando Bus Station to Jacksonvillebus bus FlixBus 2433 / ...
    11h 30m
    $79–129

  6. Bus to Fort Lauderdale–Hollywood International Airport, fly

    1. Take the bus from Fort Myers Bus Stop to Fort Lauderdale International Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Jacksonville (JAX)plane plane FLL - JAX
    6h 42m
    $200–706

  7. Bus to Miami International Airport, fly

    1. Take the bus from Fort Myers 7-11 to Miami Airportbus bus
    2. Fly from Miami International Airport (MIA) to Jacksonville (JAX)plane plane MIA - JAX
    7h 24m
    $159–494

Ft. Myers (RSW) to Jacksonville (JAX) flights

Calendar75Weekly Planes
Duration5h 15mAverage Duration
Ticket$109Cheapest Price
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Questions & Answers

Map of how to get from Sanibel Island to Jacksonville.ExpandLaunch map view
  • Distance: 347.3 mi
  • Duration: 8h 31m

What companies run services between Sanibel Island, FL, USA and Jacksonville, FL, USA?

You can take a vehicle from Sanibel Island to Jacksonville via Fort Myers 7-11, University of South Florida, and Gainesville in around 8h 31m. Alternatively, Delta, American Airlines, and two other airlines fly from Ft. Myers (RSW) to Jacksonville (JAX) every 2 hours.

Airlines
Train operators
Bus operators

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