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How to get fromSanibel Island to Key Largoby taxi, bus, car, bus (Greyhound), bus (Flixbus, Greyhound), or train

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There are 5 ways to get from Sanibel Island to Key Largo by taxi, bus, car, bus (Greyhound), bus (Flixbus, Greyhound), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi, bus

    best
    1. Take the taxi from Sanibel Island to Naplestaxi taxi
    2. Take the bus from Naples to Miami Airportbus bus
    3. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    5h 31m
    $189–254

  2. Drive 183.7 mi

    cheapest
    1. Drive from Sanibel Island to Key Largocar car 183.7 mi
    3h 49m
    $34–49

  3. Bus

    1. Take the bus from Fort Myers to Miami Airportbus bus Tallahassee–Miami via Tampa / ...
    2. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus Greyhound US0720s
    5h 57m
    $137–201

  4. Bus via South Fort Myers Transfer/P&R

    1. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus FlixBus 2421
    2. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus Greyhound US0720s
    8h
    $71–109

  5. Line 50 bus, line 140 bus, bus, line 2600 train, line 602 bus

    1. Take the bus from Mcgregor Blvd @ Davis Rd to South Fort Myers Transfer/P&Rbus bus 50
    2. Take the bus from South Fort Myers Transfer/P&R to Rosa Parks Transportation Ctrbus bus 140
    3. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus
    4. Take the train from Miami Airport Station to Dadeland South Stat.Rail Southboundtrain train
    5. Take the bus from Dadeland South Metrorail Station to Sw 344 St Park-And-Ridebus bus 602 / ...
    6. Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus bus 301
    9h 19m
    $56–83

Questions & Answers

Map of how to get from Sanibel Island to Key Largo.ExpandLaunch map view
  • Distance: 230.4 mi
  • Duration: 5h 31m

What companies run services between Sanibel Island, FL, USA and Key Largo, FL, USA?

You can take a vehicle from Sanibel Island to Key Largo Bus Stop via Fort Myers, Miami Airport, Miami International Airport, Miami, Airport Intermodal Station, and Miami Airport Station in around 5h 57m.

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