There are 5 ways to get from Sanibel Island to Key West by ferry, bus (Flixbus, Greyhound), car, plane, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Ferry
best- Take the ferry from Fort Myers Beach, FL to Key West, FLferry Fort Myers Beach
4h 17m$163–169Drive 280.8 mi
cheapest- Drive from Sanibel Island to Key Westcar 280.8 mi
6h 5m$52–74Bus
- Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
12h 37m$70–107Fly from Ft. Myers
- Fly from Ft. Myers (RSW) to Key West International Airport (EYW)plane RSW - EYW
5h 25m$165–515Bus to Miami International Airport, fly
- Take the bus from Fort Myers 7-11 to Miami Airportbus
- Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane MIA - EYW
5h 29m$141–345
Ft. Myers (RSW) to Key West International Airport (EYW) flights
Comparing Your Travel Options
The cheapest way to get from Sanibel Island to Key West is to drive which costs $50 - $75 and takes 6h 5m.
The fastest way to get from Sanibel Island to Key West is to ferry which takes 4h 17m and costs $160 - $170.
No, there is no direct bus from Sanibel Island to Key West. However, there are services departing from Mcgregor Blvd @ Davis Rd and arriving at N Roosevelt & 3rd Street via South Fort Myers Transfer/P&R, Fort Myers Bus Stop, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 12h 37m.
No, there is no direct ferry from Sanibel Island to Key West. However, there are services departing from Fort Myers Beach, FL and arriving at Key West, FL via . The journey, including transfers, takes approximately 4h 17m.
The distance between Sanibel Island and Key West is 148 miles. The road distance is 282.5 miles.
The best way to get from Sanibel Island to Key West without a car is to ferry which takes 4h 17m and costs $160 - $170.
It takes approximately 4h 17m to get from Sanibel Island to Key West, including transfers.
Sanibel Island to Key West bus services, operated by Flixbus USA, depart from Fort Myers Bus Stop station.
The best way to get from Sanibel Island to Key West is to bus which takes 12h 37m and costs $70 - $110. Alternatively, you can fly, which costs $160 - $550 and takes 5h 25m.
Sanibel Island to Key West bus services, operated by Flixbus USA, arrive at Miami Airport Station.
What companies run services between Sanibel Island, FL, USA and Key West, FL, USA?
Key West Express operates a ferry from Fort Myers Beach, FL to Key West, FL once daily. Tickets cost $130 and the journey takes 4h. Alternatively, you can take a vehicle from Sanibel Island to N Roosevelt & 3rd Street via Mcgregor Blvd @ Davis Rd, South Fort Myers Transfer/P&R, Fort Myers Bus Stop, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 12h 37m.
- Website
- aa.com
Flights from Ft. Myers to Key West International Airport via Charlotte
- Ave. Duration
- 6h 25m
- When
- Thursday, Friday, Sunday, Tuesday, and Wednesday
- Estimated price
- $95–450
Flights from Miami International Airport to Key West International Airport
- Ave. Duration
- 1h 1m
- When
- Every day
- Estimated price
- $26–200
- Website
- delta.com
Flights from Ft. Myers to Key West International Airport via Atlanta
- Ave. Duration
- 5h 22m
- When
- Every day
- Estimated price
- $85–420
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Fort Myers Bus Stop to Miami Airport Station
- Ave. Duration
- 3h 5m
- Frequency
- 3 times a day
- Estimated price
- $25–40
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $22–35
- Website
- Greyhound
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Street
- Ave. Duration
- 1h 9m
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- Key West Transit
- Phone
- +1 877 733 0724
- Website
- RedCoach
Bus from Fort Myers 7-11 to Miami Airport
- Ave. Duration
- 2h 50m
- Frequency
- Once daily
- Estimated price
- $35–50
- Website
- RedCoach
- Phone
- +1 239-463-5733
- Website
- Key West Express
Ferry from Fort Myers Beach, FL to Key West, FL
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $130
- Website
- Key West Express
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Booking & Getting There
Yes, the driving distance between Sanibel Island to Key West is 282 miles. It takes approximately 6h 5m to drive from Sanibel Island to Key West.
There are 920+ hotels available in Key West.