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How to get fromSanibel Island to Mobileby plane, bus (Greyhound), car, bus, or bus (Flixbus, Greyhound)

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There are 5 ways to get from Sanibel Island to Mobile by plane, bus (Greyhound), car, bus, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mobile Regional Airport

    best
    1. Fly from Ft. Myers (RSW) to Mobile Regional Airport (MOB)plane plane RSW - MOB
    4h 59m
    $189–612

  2. Drive  621 mi

    cheapest
    1. Drive from Sanibel Island to Mobilecar car 621 mi
    11h 10m
    $114–164

  3. Bus via Gainesville

    1. Take the bus from Fort Myers 7-11 to University of Florida - 1956 Gale Lemerand Drbus bus
    2. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Tallahassee - FSU - Old St Augustine at Intramural Fieldbus bus
    3. Take the bus from Tallahassee to Mobile Bus Stationbus bus
    18h 5m
    $211–299

  4. Fly to Pensacola International Airport, bus

    1. Fly from Ft. Myers (RSW) to Pensacola International Airport (PNS)plane plane RSW - PNS
    2. Take the bus from Pensacola Airport to Mobile Bus Stationbus bus
    8h 25m
    $129–408

  5. Bus

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the bus from Tampa Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Mobile Bus Stationbus bus
    20h 16m
    $127–198

Ft. Myers (RSW) to Mobile Regional Airport (MOB) flights

Calendar56Weekly Planes
Duration5h 49mAverage Duration
Ticket$93Cheapest Price
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Comparing Your Travel Options

Map of how to get from Sanibel Island to Mobile.ExpandLaunch map view
  • Distance: 524.2 mi
  • Duration: 4h 59m

What companies run services between Sanibel Island, FL, USA and Mobile, AL, USA?

Delta, United Airlines, and American Airlines fly from Ft. Myers (RSW) to Mobile Regional Airport (MOB) every 4 hours. Alternatively, you can take a vehicle from Sanibel Island to Govt EB at Franklin St via Fort Myers 7-11, University of Florida - 1956 Gale Lemerand Dr, Old St Augustine at Intramural Field, Tallahassee, Mobile Bus Station, and Govt EB at Greyhound Bus Station in around 18h 5m.

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