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How to get fromSanibel Island to Mobileby plane, bus (Greyhound), car, bus, or bus (Flixbus, Greyhound)

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There are 7 ways to get from Sanibel Island to Mobile by plane, bus (Greyhound), car, bus, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mobile Regional Airport

    best
    1. Fly from Ft. Myers (RSW) to Mobile Regional Airport (MOB)plane plane RSW - MOB
    7h 55m
    $176–580

  2. Drive 621 mi

    cheapest
    1. Drive from Sanibel Island to Mobilecar car 621 mi
    11h 10m
    $114–164

  3. Bus

    1. Take the bus from Fort Myers to Tallahassee FSUbus bus Miami–Tallahassee via Tampa
    2. Take the bus from Tallahassee to Mobile Bus Stationbus bus Greyhound US0799 / ...
    17h 41m
    $215–358

  4. Fly to Gulfport-Biloxi Regional Airport, bus

    1. Fly from Ft. Myers (RSW) to Gulfport-Biloxi Regional Airport (GPT)plane plane RSW - GPT
    2. Take the bus from Gulfport to Mobilebus bus
    7h 38m
    $258–771

  5. Fly to Pensacola International Airport, bus

    1. Fly from Ft. Myers (RSW) to Pensacola International Airport (PNS)plane plane RSW - PNS
    2. Take the bus from Pensacola Airport to Mobile Bus Stationbus bus
    9h 2m
    $455–909

  6. Bus via Gainesville

    1. Take the bus from Fort Myers to Tampa USFbus bus
    2. Take the bus from University of South Florida to Gainesvillebus bus
    3. Take the bus from Gainesville to Tallahasseebus bus
    4. Take the bus from Tallahassee to Mobile Bus Stationbus bus
    18h 11m
    $186–306

  7. Bus via Tampa

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the bus from Tampa Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Mobile Bus Stationbus bus
    20h 14m
    $117–219

Ft. Myers (RSW) to Mobile Regional Airport (MOB) flights

Calendar60Weekly Planes
Duration6h 20mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Sanibel Island to Mobile.ExpandLaunch map view
  • Distance: 534.2 mi
  • Duration: 7h 55m

What companies run services between Sanibel Island, FL, USA and Mobile, AL, USA?

Delta, United Airlines, and American Airlines fly from Ft. Myers (RSW) to Mobile Regional Airport (MOB) every 3 hours. Alternatively, you can take a vehicle from Sanibel Island to Govt EB Mid Block Past Joachim St via Fort Myers, Old St Augustine at Intramural Field, Tallahassee, Mobile Bus Station, and Govt EB at Greyhound Bus Station in around 17h 41m.

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