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How to get fromSanibel Island to Myrtle Beachby plane, bus, train, or car

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There are 6 ways to get from Sanibel Island to Myrtle Beach by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Ft. Myers to Myrtle Beach

    best
    1. Fly from Ft. Myers (RSW) to Myrtle Beach (MYR)plane plane RSW - MYR
    4h 46m
    $427–704

  2. Drive 640.4 mi

    cheapest
    1. Drive from Sanibel Island to Myrtle Beachcar car 640.4 mi
    12h 9m
    $117–169

  3. Bus, train

    1. Take the bus from Fort Myers Amtrak Bus Stop to Orlandobus bus
    2. Take the train from Orlando to Charleston Amtrak Stationtrain train
    3. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    18h 30m
    $293–495

  4. Fly Ft. Myers to Wilmington International Airport, bus

    1. Fly from Ft. Myers (RSW) to Wilmington International Airport (ILM)plane plane RSW - ILM
    2. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    5h 19m
    $331–681

  5. Bus to Fort Lauderdale–Hollywood International Airport, fly to Myrtle Beach

    1. Take the bus from Fort Myers Bus Stop to Fort Lauderdale International Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Myrtle Beach (MYR)plane plane FLL - MYR
    5h 47m
    $231–582

  6. Bus, train via Kissimmee

    1. Take the bus from Fort Myers Bus Stop to Orlandobus bus
    2. Take the train from Kissimmee Amtrak Station to Charleston Amtrak Stationtrain train
    3. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    22h 5m
    $204–405

Ft. Myers (RSW) to Myrtle Beach (MYR) flights

Calendar60Weekly Planes
Duration5h 22mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Sanibel Island to Myrtle Beach.ExpandLaunch map view
  • Distance: 549.2 mi
  • Duration: 4h 46m

What companies run services between Sanibel Island, FL, USA and Myrtle Beach, SC, USA?

American Airlines, Delta, and Southwest Airlines fly from Ft. Myers (RSW) to Myrtle Beach (MYR) every 3 hours.

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