Rome2Rio

How to get fromSanibel Island to Panama City Beachby plane, bus (Flixbus, Greyhound), or car

Find Transport to Panama City Beach

See all options

There are 5 ways to get from Sanibel Island to Panama City Beach by plane, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Florida Beaches International Airport

    best
    1. Fly from Ft. Myers (RSW) to Northwest Florida Beaches International Airport (ECP)plane plane RSW - ECP
    5h
    $216–625

  2. Drive 478.2 mi

    cheapest
    1. Drive from Sanibel Island to Panama City Beachcar car 478.2 mi
    9h 16m
    $88–127

  3. Bus via Gainesville

    1. Take the bus from Fort Myers 7-11 to University of South Florida - 3801 USF Holly Drbus bus
    2. Take the bus from University of South Florida to Gainesvillebus bus
    3. Take the bus from Gainesville to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    12h 55m
    $168–268

  4. Fly to Destin–Fort Walton Beach Airport, drive

    1. Fly from Ft. Myers (RSW) to Destin–Fort Walton Beach Airport (VPS)plane plane RSW - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    5h 58m
    $176–586

  5. Bus

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the bus from Tampa Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    15h 35m
    $102–176

Ft. Myers (RSW) to Northwest Florida Beaches International Airport (ECP) flights

Calendar64Weekly Planes
Duration5h 33mAverage Duration
Ticket$91Cheapest Price
See schedules

Questions & Answers

Map of how to get from Sanibel Island to Panama City Beach.ExpandLaunch map view
  • Distance: 403.6 mi
  • Duration: 5h

What companies run services between Sanibel Island, FL, USA and Panama City Beach, FL, USA?

Delta, Southwest Airlines, and American Airlines fly from Ft. Myers (RSW) to Northwest Florida Beaches International Airport (ECP) every 3 hours. Alternatively, you can take a vehicle from Sanibel Island to Panama City Beach via Fort Myers 7-11, University of South Florida, Gainesville, Tallahassee, and Panama City Beach Bus Station in around 12h 55m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers